Progress towards a highly efficient and accurate platform for enantiomeric excess determination

Enantiomeric excess (ee) determination remains as the bottleneck for high throughput screening of asymmetric catalysts. The work described herein sought to expand on two previously developed ee sensing assays from our lab– an iron based amine assembly and a zinc based multicomponent assembly. To start, the substituent effect of the zinc multicomponent dynamic assembly for secondary chiral alcohol ee determination was investigated. A new assembly with a higher dynamic range and smaller error was observed. Additionally, potential cooperative binding to the multicomponent assembly was investigated. Furthermore, this work included some preliminary results for a concurrent sensing platform for molecules with chiral amine and alcohol moieties.