Progress towards a highly efficient and accurate platform for enantiomeric excess determination

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dc.contributor.advisorAnslyn, Eric V., 1960-en
dc.contributor.committeeMemberSessler, Jonathan Len
dc.contributor.committeeMemberKeatinge-Clay, Adrianen
dc.contributor.committeeMemberJones, Richard Aen
dc.creatorLin, Chung-Yonen
dc.date.accessioned2016-08-25T17:57:00Z
dc.date.accessioned2018-01-22T22:30:30Z
dc.date.available2016-08-25T17:57:00Z
dc.date.available2018-01-22T22:30:30Z
dc.date.issued2016-05
dc.date.submittedMay 2016
dc.date.updated2016-08-25T17:57:00Z
dc.description.abstractEnantiomeric excess (ee) determination remains as the bottleneck for high throughput screening of asymmetric catalysts. The work described herein sought to expand on two previously developed ee sensing assays from our lab– an iron based amine assembly and a zinc based multicomponent assembly. To start, the substituent effect of the zinc multicomponent dynamic assembly for secondary chiral alcohol ee determination was investigated. A new assembly with a higher dynamic range and smaller error was observed. Additionally, potential cooperative binding to the multicomponent assembly was investigated. Furthermore, this work included some preliminary results for a concurrent sensing platform for molecules with chiral amine and alcohol moieties.en
dc.description.departmentChemistryen
dc.format.mimetypeapplication/pdfen
dc.identifierdoi:10.15781/T2W66986Pen
dc.identifier.urihttp://hdl.handle.net/2152/39663en
dc.language.isoenen
dc.subjectSupramolecular chemistry
dc.subjectChiroptical
dc.titleProgress towards a highly efficient and accurate platform for enantiomeric excess determinationen
dc.typeThesisen
dc.type.materialtexten

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