Role of Mash1-E Protein Heterodimers in Mash1 Function in the Developing Neural Tube
| dc.contributor.advisor | Lu, Qing Richard | en |
| dc.creator | Collisson, Tandi Louise | en |
| dc.date.accessioned | 2010-07-12T19:00:19Z | en |
| dc.date.accessioned | 2014-02-19T22:00:12Z | |
| dc.date.available | 2010-07-12T19:00:19Z | en |
| dc.date.available | 2014-02-19T22:00:12Z | |
| dc.date.issued | 2003-05-01 | en |
| dc.description.abstract | Neural-specific Class II bHLH transcription factors heterodimerize with ubiquitous Class I bHLH E proteins to form complexes required for neural differentiation. There are four known E proteins, HEB, E12, E47 and E2.2, in the mammalian nervous system, which potentially form heterodimers with Mash1 in the neural tube. To test the relevance of particular Mash1-E protein heterodimer combinations in vivo, I constructed tethered Mash1-E protein heterodimers for over-expression in the chick neural tube. By comparing overexpression of Mash1 with over-expression of these Mash1-E protein heterodimers, their abilities to effect neural differentiation and cell-type specification were analyzed. Mash1-E protein heterodimers are interchangeable in the function of driving neurogenesis in the chick neural tube. The effects of Mash1-E protein heterodimers on cell-type specificity were different, suggesting non-redundant functions in effecting dorsal interneuron populations. Furthermore, additional Mash1 heterodimer partners may be required for the cell-type specification function of Mash1. | en |
| dc.format.digitalOrigin | born digital | en |
| dc.format.medium | Electronic | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.other | en | |
| dc.identifier.uri | http://hdl.handle.net/2152.5/762 | en |
| dc.language.iso | en | en |
| dc.subject | Neurogenesis | en |
| dc.subject | Interneurons | en |
| dc.subject | Basic Helix-Loop-Helix Transcription Factors | en |
| dc.title | Role of Mash1-E Protein Heterodimers in Mash1 Function in the Developing Neural Tube | en |
| dc.type.genre | dissertation | en |
| dc.type.material | Text | en |
| thesis.date.available | 2004-04-23 | en |
| thesis.degree.department | en | |
| thesis.degree.discipline | en | |
| thesis.degree.grantor | Graduate School of Biomedical Sciences | en |
| thesis.degree.level | M.S. | en |
| thesis.degree.name | Master of Science | en |