Assessing patient quality of life, symptoms, treatment satisfaction, work productivity, and experiences with TYSABRI® therapy for Crohn’s disease in a usual care setting
dc.contributor.advisor | Lawson, Kenneth Allen, 1952- | en |
dc.contributor.committeeMember | BARNER, JAMIE C. | en |
dc.contributor.committeeMember | HASS, STEVEN L. | en |
dc.contributor.committeeMember | RASCATI, KAREN L. | en |
dc.contributor.committeeMember | WILSON, JAMES P. | en |
dc.creator | Nag, Arpita | en |
dc.date.accessioned | 2012-02-06T19:13:36Z | en |
dc.date.accessioned | 2017-05-11T22:24:08Z | |
dc.date.available | 2012-02-06T19:13:36Z | en |
dc.date.available | 2017-05-11T22:24:08Z | |
dc.date.issued | 2011-12 | en |
dc.date.submitted | December 2011 | en |
dc.date.updated | 2012-02-06T19:13:48Z | en |
dc.description | text | en |
dc.description.abstract | This study examines the effects of TYSABRI on the health-related quality of life (HrQoL) outcomes, disease status and symptomatology, treatment satisfaction, productivity outcomes and healthcare utilization for patients with Crohn’s Disease (CD). A total of 241 patients consented to participate in the study, out of which 61 patients qualified for the baseline survey. After three-months of TYSABRI therapy, the follow-up survey was completed by 24 patients. Changes in outcome scores from baseline to the three-month follow-up were evaluated. The 24 patients with the three-month follow-up were, on average 41 years old and 62.5% percent were female. For those with follow-up, a significantly lower proportion of patients (41.7 percent) identified their CD severity as moderate to severe compared to 83.3 percent at baseline (p=0.001). The patients also reported experiencing a significantly lower mean number of CD relapses at follow-up (4.0) compared to baseline (6.8) (p=0.004). Improved median well-being scores (2.0 vs. 1.0; p<0.001) and improved median abdominal pain scores (2.0 vs. 1.0; p=0.001) were also reported at follow-up. The patient global assessment of HrQoL over the last 2 weeks was significantly improved at follow-up (2.0 vs. 3.0; p=0.006). Similar improved results were observed regarding their assessment of the impact of CD on HrQoL (7.0 vs. 5.0; p<0.001). A significant change of 32.0 points on the total Inflammatory Bowel Disease Questionnaire (IBDQ) scale (p<0.001) and significant improvements in each of the four component scales were also seen at follow-up (p≤0.05). Significant improvement was noted on the SF-36 PCS scale (mean change 7.0; p=0.001) and MCS scale (mean change 6.0; p=0.05). Significant improvements were observed in the scores for each of the four scales of the treatment satisfaction questionnaire at follow-up: effectiveness scale (28.6 vs. 63.0; p<0.001); side-effects scale (61.6 vs. 82.2; p=0.01); convenience scale (63.8 vs. 70.8; p=0.05); and global satisfaction scale (41.3 vs. 67.0; p<0.001). A significant decrease in the number of CD-related emergency room (ER) visits was observed between baseline and follow-up (1.3 vs. 0.7; p=0.03). For the productivity outcomes, the percent of planned household work lost due to absenteeism was significantly reduced (73.1 percent vs. 43.9 percent; p=0.02) and the total percent of planned hours lost was also reduced (87.3 percent vs. 64.4 percent; p=0.037). These results indicate that TYSABRI is associated with significant improvement in HrQoL outcomes, CD disease severity, treatment satisfaction, ER visits and productivity outcomes. | en |
dc.description.department | Pharmacy | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.slug | 2152/ETD-UT-2011-12-4897 | en |
dc.identifier.uri | http://hdl.handle.net/2152/ETD-UT-2011-12-4897 | en |
dc.language.iso | eng | en |
dc.subject | Crohn's disease | en |
dc.subject | TYSABRI | en |
dc.subject | Health related quality of life | en |
dc.subject | Symptoms | en |
dc.title | Assessing patient quality of life, symptoms, treatment satisfaction, work productivity, and experiences with TYSABRI® therapy for Crohn’s disease in a usual care setting | en |
dc.type.genre | thesis | en |