Structural studies of ribosomal RNA based on cross-analysis of comparative models and three-dimensional crystal structures

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dc.contributor.advisorWhitman, Christian P.en
dc.contributor.advisorGutell, Robinen
dc.creatorLee, Jung Chullen
dc.date.accessioned2008-08-28T21:33:00Zen
dc.date.available2008-08-28T21:33:00Zen
dc.date.issued2003en
dc.descriptiontexten
dc.description.abstractBasepair mapping of the rRNAs in the high-resolution crystal structures of the Thermus thermophilus 30S and Haloarcula marismortui 50S ribosomal subunits not only proved the authenticity of covariation analysis in predicting RNA secondary structures with high accuracy, but also provided a great wealth of information on RNA structure, ranging from diverse basepair conformations to structure motifs. Based on cross-analysis of comparative structure models and crystal structures of rRNAs, a systematic and unambiguous classification for basepair conformations is established, and the structural features and biological implications for a wide variety of RNA sequence and structure motifs, including the AA.AG@helix.ends motif, the sticky motif consisting of AGUA/GAA, GUA/GAA, and GGA/GAA motifs, and the lonepair triloop motif, are discussed.
dc.description.departmentPharmacyen
dc.format.mediumelectronicen
dc.identifierb56868133en
dc.identifier.oclc56313999en
dc.identifier.proqst3119630en
dc.identifier.urihttp://hdl.handle.net/2152/731en
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.subject.lcshRibosomesen
dc.subject.lcshRNAen
dc.subject.lcshCrystallographyen
dc.titleStructural studies of ribosomal RNA based on cross-analysis of comparative models and three-dimensional crystal structuresen
dc.type.genreThesisen

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