Palladium-mediated cyclizations of gamma-oxoallenes: synthesis of structurally modified nucleic acids
dc.creator | Mosher, Michael D. | |
dc.date.accessioned | 2016-11-14T23:20:07Z | |
dc.date.available | 2011-02-18T21:16:01Z | |
dc.date.available | 2016-11-14T23:20:07Z | |
dc.date.issued | 1993-08 | |
dc.degree.department | Chemistry | en_US |
dc.description.abstract | The goals of the research described in this dissertation were to study the palladium-mediated intramolecular nucleometallatlon/methoxycarbonylation of yoxoallenes (see Scheme 1) and to use the methyl furanoside products obtained from such reactions in the syntheses of deoxy- and dideoxyribonucleoside analogues. Nucleoside analogues are currently of particular interest due to their ability to act as anti-tumor and anti-AIDS (Acquired Immunodeficiency Syndrome) medicines. A section of this introduction has been dedicated to information about AIDS and antiretrovlral nucleoside analogues. A convenient route to enantiomerically pure C-nucleoslde derivatives will be mentioned as a side project. (C-Nucleosides have also been found to possess potent biological activity). In addition, the cyclizatlon of 4,5-hexadienoic acid to give butyrolactone products will be described (see Scheme 1; R'" = OH). | |
dc.format.mimetype | application/pdf | |
dc.identifier.uri | http://hdl.handle.net/2346/15818 | en_US |
dc.language.iso | eng | |
dc.publisher | Texas Tech University | en_US |
dc.rights.availability | Unrestricted. | |
dc.subject | Palladium catalysts | en_US |
dc.subject | Allene -- Synthesis | en_US |
dc.subject | Nucleic acids -- Synthesis | en_US |
dc.title | Palladium-mediated cyclizations of gamma-oxoallenes: synthesis of structurally modified nucleic acids | |
dc.type | Dissertation |