UCHLI in the Mammalian Nervous System

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dc.contributor.advisorLin, Weichunen
dc.creatorMyers, Kalisa Galinaen
dc.date.accessioned2010-07-12T17:55:58Zen
dc.date.accessioned2014-02-19T22:01:44Z
dc.date.available2010-07-12T17:55:58Zen
dc.date.available2014-02-19T22:01:44Z
dc.date.issued2008-9-18en
dc.description.abstractUCHL1, or Ubiquitin Carboxy Terminal Hydrolase L1, is a de-ubiquitinating enzyme (DUB) thought to be involved in ubiquitin recycling. Beyond this, its natural function is almost wholly unknown. Mice lacking this enzyme exhibit a severe and rapidly progressing neurodegenerative phenotype. Using one of these mouse models, in which a lacz-neo construct is cloned in under the UCHL1 promoter, we have studied the gross progression of phenotype of these mice, characterized the expression pattern of UCHLO1 in brain, spinal cord, and lumbar dorsal root ganglia, described degeneration of muscle spindles, and established a timecourse of degeneration of neuromuscular junctions. Presented in this thesis is the culmination of these studies.en
dc.format.digitalOriginborn digitalen
dc.format.mediumElectronicen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheren
dc.identifier.urihttp://hdl.handle.net/2152.5/403en
dc.language.isoenen
dc.subjectUbiquitin Thiolesteraseen
dc.subjectCentral Nervous Systemen
dc.subjectNerve Degenerationen
dc.titleUCHLI in the Mammalian Nervous Systemen
dc.type.genredissertationen
dc.type.materialTexten
thesis.date.available2009-09-18en
thesis.degree.departmenten
thesis.degree.disciplineNeuroscienceen
thesis.degree.grantorGraduate School of Biomedical Sciencesen
thesis.degree.levelM.S.en
thesis.degree.nameMaster of Scienceen

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University of Texas Southwestern Medical Center