Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development

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dc.contributor.advisorKenneth M. Johnson, PhD.en_US
dc.contributor.committeeMemberKathryn Cunningham, PhD.en_US
dc.contributor.committeeMemberGiulio Taglialatela, PhD.en_US
dc.contributor.committeeMemberGeoffrey T. Swansonen_US
dc.creatorNoelle Catherine Anastasioen_US
dc.date.accessioned2011-12-20T16:04:59Z
dc.date.accessioned2014-02-19T22:05:22Z
dc.date.available2008-06-17en_US
dc.date.available2011-12-20T16:04:59Z
dc.date.available2014-02-19T22:05:22Z
dc.date.created2005-07-20en_US
dc.date.issued2005-07-06en_US
dc.description.abstractDisruptions in glutamatergic neurotransmission may play a role in the pathogenesis of schizophrenia. The purpose of this study was to determine phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition (PPI) caused by PCP treatment. Postnatal rats were treated with atypical or typical antipsychotics or selective dopamine or serotonin receptor antagonists prior to acute or sub-chronic PCP. This study provides evidence that two distinct mechanisms underlie effects of acute and sub-chronic PCP on NMDA receptor subunit up-regulation. Furthermore, we discovered that D1, D2, and 5-HT2A receptors play a pivotal role in sub-chronic PCP-induced up-regulation of NR1 and NR2A. Finally, we were able to correlate changes in NMDA receptor subunits to the behavioral effects of PCP in this animal model of schizophrenia.en_US
dc.format.mediumelectronicen_US
dc.identifier.otheretd-07202005-145246en_US
dc.identifier.urihttp://hdl.handle.net/2152.3/170
dc.language.isoengen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjectschizophreniaen_US
dc.subjectolanzapineen_US
dc.subjectanimal modelen_US
dc.titleRegional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during developmenten_US
dc.type.genrethesisen_US
dc.type.materialtexten_US
thesis.degree.departmentPharmacology and Toxicologyen_US
thesis.degree.grantorThe University of Texas Medical Branchen_US
thesis.degree.levelMasteren_US
thesis.degree.nameMaster of Scienceen_US

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