Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development

dc.contributor.advisorKenneth M. Johnson, PhD.en_US
dc.contributor.committeeMemberKathryn Cunningham, PhD.en_US
dc.contributor.committeeMemberGiulio Taglialatela, PhD.en_US
dc.contributor.committeeMemberGeoffrey T. Swansonen_US
dc.creatorNoelle Catherine Anastasioen_US
dc.description.abstractDisruptions in glutamatergic neurotransmission may play a role in the pathogenesis of schizophrenia. The purpose of this study was to determine phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition (PPI) caused by PCP treatment. Postnatal rats were treated with atypical or typical antipsychotics or selective dopamine or serotonin receptor antagonists prior to acute or sub-chronic PCP. This study provides evidence that two distinct mechanisms underlie effects of acute and sub-chronic PCP on NMDA receptor subunit up-regulation. Furthermore, we discovered that D1, D2, and 5-HT2A receptors play a pivotal role in sub-chronic PCP-induced up-regulation of NR1 and NR2A. Finally, we were able to correlate changes in NMDA receptor subunits to the behavioral effects of PCP in this animal model of schizophrenia.en_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjectanimal modelen_US
dc.titleRegional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during developmenten_US
dc.type.materialtexten_US and Toxicologyen_US University of Texas Medical Branchen_US of Scienceen_US