Development of a multiphysics model for blood flow and drug transport with application to patient-specific coronary artery flow



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A multiphysics model of blood flow and drug dispersion has been constructed for a section of coronary artery. Using NURBS-based isogeometric technology to describe the geometry, I model the release of a liquid drug into the bloodstream as well as its transport and deposition into the arterial lumen. This model includes fluid-structure interaction between the blood and the arterial wall, a porous-media model governing the penetration of fluid into the arterial lumen, and a scalar advection-diffusion equation describing the drug. I present a numerical method for coupling the fluid and porous-media equations. I use this methodology to simulate patient-specific geometries with a set of physically relevant parameters.