The flavonoids and phenolic acids of the genus Silphium and their chemosystematic and medicinal value
dc.contributor.advisor | Mabry, T. J. (Tom J.) | en |
dc.contributor.advisor | Roux, Stanley J. | en |
dc.creator | Williams, Jeffrey Douglas | en |
dc.date.accessioned | 2008-08-28T23:52:40Z | en |
dc.date.available | 2008-08-28T23:52:40Z | en |
dc.date.issued | 2006 | en |
dc.description.abstract | My chemistry studies of the genus Silphium involved the flavonoids and phenolic acids among eleven species. In the course of these investigations, five new flavonol triglycosides were isolated and characterized: isorhamnetin 3-O-α-L-rhamnosyl (1'''→6'')- O-β-D-galactopyranoside 7-O-β-L-apiofuranoside (1A), quercetin 3-O-α-L-rhamnosyl (1'''→6'')-O-β-D-galactopyranoside 7-O-β-L-apiofuranoside (2A), quercetin 3-O-β-Lgalactosyl (1'''→6'')-O-β-D-rhamnopyranoside 7-O-α-L-apiofuranoside (3A), kaempferol 3-O-β-D-apiofuranoside 7-O-α-L-rhamnosyl (1''''→6''')-O-β-D-galactopyranoside (4A) and kaempferol 3-O-β-D-apiofuranoside 7-O-α-L-rhamnosyl (1''''→6''')-O-β-D (2'''-O-E- caffeoylgalactopyranoside) (5A). Many other known mono and diglycosidic flavonoids were also isolated and identified. The structures of all these compounds were established by chemical methods and spectral analyses using 1 H NMR, 13C NMR, HMQC, HMBC, ROESY, TOCSY and LC/MS techniques. The distribution of the flavonoids and phenolic acids in all eleven members were compared with Dr. Jennifer Clevinger’s DNA-based revision of the genus. In addition to the detailed chemical investigations, I present my evaluations of the chemosystematic and medicinal value of the compounds I characterized; moreover, the new flavonoids are now being made available for medicinal and pharmaceutical studies. | |
dc.description.department | Biological Sciences, School of | en |
dc.format.medium | electronic | en |
dc.identifier.oclc | 182860145 | en |
dc.identifier.uri | http://hdl.handle.net/2152/3514 | en |
dc.language.iso | eng | en |
dc.rights | Copyright © is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works. | en |
dc.subject.lcsh | Silphium (Genus) | en |
dc.subject.lcsh | Flavonoids | en |
dc.subject.lcsh | Phenolic acids | en |
dc.subject.lcsh | Materia medica, Vegetable | en |
dc.title | The flavonoids and phenolic acids of the genus Silphium and their chemosystematic and medicinal value | en |
dc.type.genre | Thesis | en |