Development of methodologies employing rhodium catalysis and studies toward the total synthesis of cortistatin A

Simple item page
dc.contributor.advisorMartin, Stephen F.en
dc.contributor.committeeMemberBielawski, Christopheren
dc.contributor.committeeMemberLaude, Daviden
dc.contributor.committeeMemberKerwin, Seanen
dc.contributor.committeeMemberSessler, Jonathanen
dc.creatorSmith, Anna Jane, Ph. D.en
dc.date.accessioned2010-08-23T17:50:37Zen
dc.date.accessioned2010-08-23T17:50:55Zen
dc.date.accessioned2017-05-11T22:20:05Z
dc.date.available2010-08-23T17:50:37Zen
dc.date.available2010-08-23T17:50:55Zen
dc.date.available2017-05-11T22:20:05Z
dc.date.issued2009-12en
dc.date.submittedDecember 2009en
dc.date.updated2010-08-23T17:50:55Zen
dc.descriptiontexten
dc.description.abstract[Rh(CO]2Cl]2 has been shown to catalyze sequential, mechanistically- distinct transformations in one pot. Tandem allylic alkylation/cycloisomerization sequences have been developed to access valuable, complex structures from relatively simple substrates. A methodology for the enantioselective conjugate addition of 2-heteroaryl nucleophiles to a variety of Michael acceptors has been developed. This method was used successfully in an ongoing approach to the synthesis of cortistatin A. 10 linear steps have been completed towards the synthesis of cortistatin A, including a highly regioselective propargylation to install a quaternary carbon and a diastereoselective intramolecular Diels-Alder reaction.en
dc.format.mimetypeapplication/pdfen
dc.identifier.urihttp://hdl.handle.net/2152/ETD-UT-2009-12-653en
dc.language.isoengen
dc.subjectCortistatin Aen
dc.subjectTandem catalysisen
dc.subjectEnantioselective conjugate additionen
dc.titleDevelopment of methodologies employing rhodium catalysis and studies toward the total synthesis of cortistatin Aen
dc.type.genrethesisen

Files

Collections

University of Texas at Austin