Buprenorphine metabolism by preterm placentas: A pilot study

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dc.contributor.advisorIrina Pikulevaen_US
dc.contributor.committeeMemberPatricia Shinnick-Gallagheren_US
dc.contributor.committeeMemberMary Treinen-Moslenen_US
dc.contributor.committeeMemberKenneth M. Johnsonen_US
dc.creatorRachel McRee Kaufmanen_US
dc.date.accessioned2011-12-20T16:05:31Z
dc.date.accessioned2014-02-19T22:05:40Z
dc.date.available2008-06-17en_US
dc.date.available2011-12-20T16:05:31Z
dc.date.available2014-02-19T22:05:40Z
dc.date.created2007-11-14en_US
dc.date.issued2007-10-31en_US
dc.description.abstractThe focus of this investigation is to attempt to identify and characterize the major enzyme responsible for metabolism of buprenorphine to nor-buprenorphine in human preterm placentas and to elucidate whether the development/gestational age of the placenta affects metabolism of buprenorphine. The estimated apparent Km did not appear to change with gestational age suggesting the affinity of buprenorphine does not change throughout gestation. On the other hand, the estimated Vmax did appear to increase with gestational age suggesting the activity increases with gestational age. Our attempt to identify the enzyme responsible for metabolism in earlier gestational age placentas revealed that CYP19 remains the major metabolizing enzyme of buprenorphine but suggests additional enzymes may be involved, namely, CYP3A4, 1A1, 2E1, 2D6 and 2C19. Further studies must be conducted for conclusions to be drawn but we hope this report can contribute to the design of future studies on preterm placental metabolism of drugs.en_US
dc.format.mediumelectronicen_US
dc.identifier.otheretd-11142007-200615en_US
dc.identifier.urihttp://hdl.handle.net/2152.3/254
dc.language.isoengen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjectpregnancyen_US
dc.subjecthuman placental aromatase/ CYP19en_US
dc.subjectbuprenorphineen_US
dc.titleBuprenorphine metabolism by preterm placentas: A pilot studyen_US
dc.type.genrethesisen_US
dc.type.materialtexten_US
thesis.degree.departmentPharmacology and Toxicologyen_US
thesis.degree.grantorThe University of Texas Medical Branchen_US
thesis.degree.levelMasteren_US
thesis.degree.nameMaster of Scienceen_US

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