Mechanisms underlying the dysregulation of postural stability in dopamine-depleted rates

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dc.contributor.advisorSchallert, Timothyen
dc.creatorWoodlee, Martin Thomas, 1977-en
dc.date.accessioned2012-09-10T17:31:55Zen
dc.date.accessioned2017-05-11T22:27:20Z
dc.date.available2012-09-10T17:31:55Zen
dc.date.available2017-05-11T22:27:20Z
dc.date.issued2008-05en
dc.descriptiontexten
dc.description.abstractThe work described in this dissertation aims to understand how postural instability (PI), a troubling symptom of advanced Parkinson's disease (PD) in humans, develops from the degeneration of nigrostriatal dopamine neurons characteristic of PD. The studies herein (1) outline the development of clinically relevant methods for evaluating PI in experimental rodents, (2) indicate that PI may not result directly from disruption of dopamine systems but may instead arise from non-dopaminergic changes that occur subsequent to dopamine depletion, and (3) search for specific evidence of plasticity or degeneration outside of the damaged nigrostriatal dopamine system that may be linked to the development of PI. It is hoped that this work will help lay the foundation for the development of novel prophylactic treatments aimed at preventing the progression of PD to advanced stages where treatment-resistant symptoms such as PI appear.en
dc.description.departmentNeuroscienceen
dc.format.mediumelectronicen
dc.identifier.urihttp://hdl.handle.net/2152/17830en
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.subject.lcshEquilibriumen
dc.subject.lcshDopamineen
dc.subject.lcshParkinson's disease--Animal modelsen
dc.titleMechanisms underlying the dysregulation of postural stability in dopamine-depleted ratesen

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