The evolution of RNA and the actin protein family

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dc.contributor.advisorBull, James J.en
dc.contributor.advisorWilke, C. (Claus)en
dc.contributor.committeeMemberJuenger, Thomasen
dc.contributor.committeeMemberMeyers, Lauren Aen
dc.contributor.committeeMemberSawyer, Sara Len
dc.creatorKeller, Thomas E.en
dc.date.accessioned2015-08-20T19:29:46Zen
dc.date.accessioned2018-01-22T22:27:56Z
dc.date.available2018-01-22T22:27:56Z
dc.date.issued2012-05en
dc.date.submittedMay 2012en
dc.date.updated2015-08-20T19:29:46Zen
dc.description.abstractIn my dissertation I have broadly studied the evolution of RNA as well as the phylogenetic history of the actin protein family. In the first chapter I examined how various evolutionary processes interact at high mutation rates, which led to simple prediction based on the strength of selection. In the second chapter, I tested mRNA secondary structure stability at the beginning of genes as a way of identifying whether putative genes might be functional or not. Finally, I reconstructed the phylogenetic history of the actin protein family in vertebrates, revealing that a novel isoform is actively evolving in contrast to the remaining protein isoforms.en
dc.description.departmentEcology, Evolution and Behavioren
dc.format.mimetypeapplication/pdfen
dc.identifier.urihttp://hdl.handle.net/2152/30391en
dc.subjectmRNAen
dc.subjectRNAen
dc.subjectEvolutionen
dc.subjectHigh mutation ratesen
dc.subjectActin phylogenyen
dc.titleThe evolution of RNA and the actin protein familyen
dc.typeThesisen

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