Photoacoustic imaging for temperature monitoring and photothermal therapy guidance

Simple item page
dc.contributor.advisorEmelianov, Stanislav Y.en
dc.contributor.committeeMemberAglyamov, Salavaten
dc.contributor.committeeMemberCook, Jasonen
dc.creatorDumani Jarquin, Diego Sayeden
dc.date.accessioned2015-10-16T16:58:48Zen
dc.date.accessioned2018-01-22T22:28:29Z
dc.date.available2015-10-16T16:58:48Zen
dc.date.available2018-01-22T22:28:29Z
dc.date.issued2015-08en
dc.date.submittedAugust 2015en
dc.date.updated2015-10-16T16:58:48Zen
dc.descriptiontexten
dc.description.abstractCancer is among the leading causes of death in the United States and the world. Using combined ultrasound (US) and photoacoustic (PA) imaging can provide both anatomical and molecular information of cancerous cells for both diagnostic and therapeutic purposes. This thesis is focused on combining these two modalities, in conjunction with nanoparticles, to treat cancerous tumors and monitor the progress of the therapy. Specifically, the work evaluates the use of photoacoustic imaging as a temperature monitoring tool during photothermal therapy. In this study, the mathematical relationship between photoacoustic signal and temperature is presented and validated with a glass tube phantom using gold nanoparticles. Then in vitro and ex vivo studies were performed to validate the effect of photothermal therapy and the monitoring capability of photoacoustic imaging. The results show that photoacoustic imaging can be used to monitor temperature during photothermal therapy. Future directions include in vivo studies of image guided photothermal therapy and survival studies.en
dc.description.departmentBiomedical Engineeringen
dc.format.mimetypeapplication/pdfen
dc.identifierdoi:10.15781/T2WC8Zen
dc.identifier.urihttp://hdl.handle.net/2152/31748en
dc.language.isoenen
dc.subjectUltrasounden
dc.subjectPhotoacousticen
dc.subjectImagingen
dc.subjectNanoparticlesen
dc.subjectContrast agentsen
dc.subjectPhotothermal therapyen
dc.subjectCanceren
dc.titlePhotoacoustic imaging for temperature monitoring and photothermal therapy guidanceen
dc.typeThesisen

Files

Collections

University of Texas at Austin