Role of Repressors in Fine Regulation of Development: Sxl and Its New Repressors Hey and Myc

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dc.creatorKozhina, Elena
dc.date.accessioned2010-07-15T00:15:15Z
dc.date.accessioned2010-07-23T21:46:16Z
dc.date.accessioned2017-04-07T19:57:17Z
dc.date.available2010-07-15T00:15:15Z
dc.date.available2010-07-23T21:46:16Z
dc.date.available2017-04-07T19:57:17Z
dc.date.created2009-12
dc.date.issued2010-07-14
dc.description.abstractIn Drosophila, XX embryos express Sxl from the early promoter, SxlPe, and become females. At the same time, XY embryos with only one X chromosome become males. I investigated the role of repression in the establishment of the strict regulation of SxlPe. I found that the co-repressor Groucho, is responsible for amplification of the two-fold difference in X-encoded activator genes into an all-or-nothing difference in Sxl expression. Three new basic helix-loop-helix repressors of Sxl were identified: Hey, Cwo and the prooncogene Myc, all of which are maternally supplied. I have shown that Myc specific repression is important as early as cycle 10, which is 2 cycles earlier than the onset of normal Sxl expression.
dc.identifier.urihttp://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7419
dc.language.isoeng
dc.subjectDrosophila
dc.subjectpromoter
dc.subjectrepressor
dc.subjectGroucho
dc.subjectSxl
dc.subjectHey
dc.subjectCwo
dc.subjectMyc.
dc.titleRole of Repressors in Fine Regulation of Development: Sxl and Its New Repressors Hey and Myc
dc.typeBook
dc.typeThesis

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