Exploring a Functional Disconnect Between Nestin-Expressing Type-1 Cells and Adult Hippocampal Neurogenesis
| dc.contributor.advisor | Eisch, Amelia J. | en |
| dc.creator | DeCarolis, Nathan Anthony | en |
| dc.date.accessioned | 2010-07-12T18:54:36Z | en |
| dc.date.accessioned | 2014-02-19T22:02:26Z | |
| dc.date.available | 2010-07-12T18:54:36Z | en |
| dc.date.available | 2014-02-19T22:02:26Z | |
| dc.date.issued | 2010-05-14 | en |
| dc.description.abstract | The subgranular zone of the hippocampal dentate gyrus generates new neurons throughout adulthood. The process of adult neurogenesis is well-described, but the source of proliferating progenitors is unknown. One potential source is the Type-1 cell, which is morphologically reminiscent of embryonic radial stem cells and expresses protein markers like nestin. However, there is no direct evidence that Type-1 cells are the source of neurogenesis. For this doctoral research, I asked two questions to gain more insight into the role of Type-1 cells in adult The subgranular zone of the hippocampal dentate gyrus generates new neurons throughout adulthood. The process of adult neurogenesis is well-described, but the source of proliferating progenitors is unknown. One potential source is the Type-1 cell, which is morphologically reminiscent of embryonic radial stem cells and expresses protein markers like nestin. However, there is no direct evidence that Type-1 cells are the source of neurogenesis. For this doctoral research, I asked two questions to gain more insight into the role of Type-1 cells in adult GL-YFP but not Nes-YFP mice showed recovery of YFP+ progenitors, suggesting that GL-YFP cells are stem-like while Nes-YFP cells are progenitor-like. This correlative and causative evidence that nestin-expressing Type-1 cells are not the source of neurogenesis significantly advances our understanding of the neurogenic process. | en |
| dc.identifier.other | 795781324 | en |
| dc.identifier.uri | http://hdl.handle.net/2152.5/718 | en |
| dc.language.iso | en | en |
| dc.subject.mesh | Intermediate Filament Proteins | en |
| dc.subject.mesh | Brain | en |
| dc.subject.mesh | Cell Lineage | en |
| dc.title | Exploring a Functional Disconnect Between Nestin-Expressing Type-1 Cells and Adult Hippocampal Neurogenesis | en |
| thesis.date.available | 2010-05-14 | en |
| thesis.degree.discipline | Integrative Biology | en |
| thesis.degree.grantor | Graduate School of Biomedical Sciences | en |
| thesis.degree.level | Ph.D. | en |
| thesis.degree.name | Doctor of Philosophy | en |