Effects of light-emitting diode photostimulation on burn wound healing

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dc.contributor.advisorLisa J. Goulden_US
dc.contributor.committeeMemberMassoud Motamedien_US
dc.contributor.committeeMemberLinda G. Phillipsen_US
dc.contributor.committeeMemberHal K. Hawkinsen_US
dc.contributor.committeeMemberGregory Asimakisen_US
dc.creatorMimi Leongen_US
dc.date.accessioned2011-12-20T16:04:32Z
dc.date.accessioned2014-02-19T22:05:02Z
dc.date.available2010-09-28en_US
dc.date.available2011-12-20T16:04:32Z
dc.date.available2014-02-19T22:05:02Z
dc.date.created2006-03-31en_US
dc.date.issued2003-06-23en_US
dc.description.abstractAnnually, more than 1.2 million persons in the United States require medical care for burns. Healing of deep burn wounds requires restored perfusion and neoangiogenesis to reestablish blood flow and limit ischemic damage.\r\nWe propose that LED photostimulation, by inducing macrophage proliferation and secretion of pro-angiogenic factors, will restore perfusion by increasing angiogenesis. \r\nAn in vitro inflammatory model and in vivo rodent thermal injury model were treated with LED at 670nm, 730nm, 880nm, or combination-670nm/730nm/880nm. Conditioned media were analyzed for VEGF and NO. Excised burn wounds underwent measurement of surface area, tensile strength, VEGF, nitrites, and immunohistochemical markers (iNOS, VEGF, cyclooxygenase-2, Factor VIII, ED-1) on days 3, 7, and 14.\r\nBoth in vitro and in vivo findings demonstrate that LED therapy has vulnerary effects on angiogenesis, by affecting macrophage production of VEGF and NO. These effects are wavelength and fluence-dependent.\r\nen_US
dc.format.mediumelectronicen_US
dc.identifier.otheretd-03312006-125427en_US
dc.identifier.urihttp://hdl.handle.net/2152.3/81
dc.language.isoengen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjectwound healingen_US
dc.subjectvascular endothelial growth factoren_US
dc.subjectphotostimulationen_US
dc.subjectnitric oxideen_US
dc.subjectcyclooxygenase-2en_US
dc.subjectangiogenesisen_US
dc.titleEffects of light-emitting diode photostimulation on burn wound healingen_US
dc.type.genrethesisen_US
dc.type.materialtexten_US
thesis.degree.departmentSurgeryen_US
thesis.degree.grantorThe University of Texas Medical Branchen_US
thesis.degree.levelMasteren_US
thesis.degree.nameMaster of Medical Scienceen_US

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