Studies directed towards the total synthesis of the natural product diazonamide A

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dc.contributor.advisorMagnus, Philip D.en
dc.creatorKreisberg, Jennifer Dianeen
dc.date.accessioned2011-03-23T21:26:21Zen
dc.date.accessioned2017-05-11T22:21:43Z
dc.date.available2011-03-23T21:26:21Zen
dc.date.available2017-05-11T22:21:43Z
dc.date.issued2001-12en
dc.descriptiontexten
dc.description.abstractThis dissertation is devoted to our synthetic studies aimed at the total synthesis of the natural product diazonamide A. Chapter 1 serves as an introduction to the diazonamides with a discussion of related marine cyclopeptides, previous synthetic work, and our retrosynthetic analysis. In Chapter 2, the development of a methodology for constructing benzofuran-2-ones related to the IHG-rings of diazonamide A using the Pummerer reaction is presented. Chapter 3 describes the preparation of bis-benzylic radicals and an examination of their chemical properties. A new methodology for the synthesis of 2,4-disubstituted oxazoles is reported in Chapter 4. Chapter 5 details the synthesis of several advanced model systems including the completion of the IHGCDEFrings. Finally, Chapter 6 contains a description of the experiments performed along with the relevant analytical data.
dc.description.departmentChemistry and Biochemistryen
dc.format.mediumelectronicen
dc.identifier.urihttp://hdl.handle.net/2152/10661en
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.rights.restrictionRestricteden
dc.subjectStereochemistryen
dc.subjectDiazonamide Aen
dc.titleStudies directed towards the total synthesis of the natural product diazonamide Aen

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