The total synthesis of (±)stepharine
| dc.contributor.advisor | Magnus, Philip D. | |
| dc.creator | Marks, Kyle David | en |
| dc.date.accessioned | 2014-04-04T14:59:10Z | en |
| dc.date.accessioned | 2017-05-11T22:49:51Z | |
| dc.date.available | 2017-05-11T22:49:51Z | |
| dc.date.issued | 2013-12 | en |
| dc.date.submitted | December 2013 | en |
| dc.date.updated | 2014-04-04T14:59:10Z | en |
| dc.description | text | en |
| dc.description.abstract | Herein is described work culminating in the total synthesis of the proaporphine alkaloid (±)stepharine. The first chapter discusses some of the background information regarding the molecule's isolation, biological activity, and previous syntheses. Chapter 2 tells of our initial attempts at synthesizing the molecule leading to the assembly of (±)stepharine's tetrahydroisoquinoline structure. Chapter 3 recounts the completion of the synthesis using an alternate route. Also described in this chapter is the use of a CsF induced intramolecular phenolic alkylation to form (±)stepharine's spiro cross conjugated dienone structure. Experimental details and characterization are included as well. | en |
| dc.description.department | Chemistry | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.uri | http://hdl.handle.net/2152/23791 | en |
| dc.subject | Stepharine | en |
| dc.title | The total synthesis of (±)stepharine | en |
| dc.type | Thesis | en |