Combined ultrasound, photoacoustic and elasticity microscope for tissue engineers

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dc.contributor.advisorEmelianov, Stanislav Y.en
dc.creatorMallidi, Srivalleeshaen
dc.date.accessioned2015-10-13T21:02:35Zen
dc.date.accessioned2018-01-22T22:28:27Z
dc.date.available2015-10-13T21:02:35Zen
dc.date.available2018-01-22T22:28:27Z
dc.date.issued2006-08en
dc.descriptiontexten
dc.description.abstractTissue engineering is an interdisciplinary field that combines various aspects of engineering and life sciences and aims to develop biological substitutes to restore, repair or maintain tissue function. Currently, the ability to have quantitative functional assays of engineered tissues is limited to existing invasive methods like biopsy. Hence, an imaging tool for non-invasive and simultaneous evaluation of the anatomical and functional properties of the engineered tissue is needed. In this thesis, we present an advanced in-vivo imaging technology - ultrasound biomicroscopy combined with complementary photoacoustic and elasticity imaging techniques, capable of accurate visualization of both structural and functional changes in engineered tissues, sequential monitoring of tissue adaptation and/or regeneration, and possible assistance of drug delivery and treatment planning. The combined imaging at microscopic resolution was evaluated on tissue mimicking phantoms imaged with 25 MHz single element focused transducer. The results of our study demonstrate that the ultrasonic, photoacoustic and elasticity images synergistically complement each other in detecting features otherwise imperceptible using the individual techniques. Finally, we illustrate the feasibility of the combined ultrasound, photoacoustic and elasticity imaging techniques in accurately assessing the morphological and functional changes occurring in engineered tissue.en
dc.description.departmentBiomedical Engineeringen
dc.format.mediumelectronicen
dc.identifierdoi:10.15781/T20897en
dc.identifier.urihttp://hdl.handle.net/2152/31724en
dc.language.isoengen
dc.relation.ispartofUT Electronic Theses and Dissertationsen
dc.rightsCopyright © is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.rights.restrictionRestricteden
dc.subjectTissue engineeringen
dc.subjectImaging technologyen
dc.subjectImaging toolsen
dc.titleCombined ultrasound, photoacoustic and elasticity microscope for tissue engineersen
dc.typeThesisen
dc.type.genreThesisen

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