Browsing by Subject "strain"
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Item A Structurally Based Investigation of Abdominal Aortic Aneurysms in Mouse Models(2012-02-14) Collins, MelissaUnderstanding the mechanical properties of Abdominal Aortic Aneurysms is paramount to improving treatment of this deadly condition. Here, we present work that makes strides in understanding not only the mechanical behavior and constitutive parameters of the two vessels that experience AAAs in different models, but also the effects of three major components of AAA formation. Biaxial mechanical tests were performed using a modified computer- controlled device. We examined the solid mechanics of the infrarenal and suprarenal aorta to examine why non-targeted models of AAAs (like Ang-II infusion) form exclusively in the suprarenal aorta whereas in humans the lesions preferentially form in the infrarenal aorta. The major difference between the two vessels is the elastin content and lamellar thickness in the suprarenal aorta. We analyzed the mechanical and constitutive effects of an acute loss of functional elastin via intraluminal exposure to elastase. We found that after elastase exposure, vessels were less distensible and experienced non-uniform, but modest dilatation. The constitutive parameters reflect elastin loss and increased collagen loading. We detailed the loss of smooth muscle cell contractility as found in human lesions that form in the thoracic aorta. We examined wild-type (WT), heterozygous (HET), and null (KO) a-smooth muscle actin (a-SMA) mice. The data and associated constitutive parameters were nearly identical amongst the three groups. We studied the biaxial mechanical tests on Angiotensin-II-infused ApoE-/- mice. This model is common model of AAA; however, instead of dilation and a thinning of the wall as in AAAs, Ang-II results in a dissecting aneurysm with adventitial growth. The pressure-diameter curves show a lack of sigmoidal shape attributed to elastin, there is some distensibility. The pressure-force behavior of these vessels is similar to a native vessel, unlike the pressure-force behavior of the elastase vessels. We have added a piece to the puzzle in understanding why AAAs occur preferentially in the suprarenal in mice as opposed to the infrarenal in humans. Our work with the a-SMA mice, introduces the idea that missense mutations in the ACTA2 gene, rather than the knocking out of the gene, leads to vascular diseases. We have increased the knowledge of the Ang-II infusion model by presenting biaxial mechanical data of the resulting dilatations. We have also further explored this widely used AAA model via histology to determine that in it is not a model for aneurysm development, but is a dissecting adventitial disease.Item Energy Transfer Dynamics and Dopant Luminescence in Mn-Doped CdS/ZnS Core/Shell Nanocrystals(2012-11-13) Chen, Hsiang-YunMn-doped II-VI semiconductor nanocrystals exhibit bright dopant photoluminescence that has potential usefulness for light emitting devices, temperature sensing, and biological imaging. The bright luminescence comes from the 4T1?6A1 transition of the Mn2+ d electrons after the exciton-dopant energy transfer, which reroutes the exciton relaxation through trapping processes. The driving force of the energy transfer is the strong exchange coupling between the exciton and Mn2+ due to the confinement of exciton in the nanocrystal. The exciton-Mn spatial overlap affecting the exchange coupling strength is an important parameter that varies the energy transfer rate and the quantum yield of Mn luminescence. In this dissertation, this correlation is studied in radial doping location-controlled Mn-doped CdS/ZnS nanocrystals. Energy transfer rate was found decreasing when increasing the doping radius in the nanocrystals at the same core size and shell thickness and when increasing the size of the nanocrystals at a fixed doping radius. In addition to the exciton-Mn energy transfer discussed above, two consecutive exciton-Mn energy transfers can also occur if multiple excitons are generated before the relaxation of Mn (lifetime ~10^-4 - 10^-2 s). The consecutive exciton-Mn energy transfer can further excite the Mn2+ d electrons high in conduction band and results in the quenching of Mn luminescence. The highly excited electrons show higher photocatalytic efficiency than the electrons in undoped nanocrystals. Finally, the effect of local lattice strain on the local vibrational frequency and local thermal expansion was observed via the temperature-dependent Mn luminescence spectral linewidth and peak position in Mn-doped CdS/ZnS nanocrystals. The local lattice strain on the Mn2+ ions is varied using the large core/shell lattice mismatch (~7%) that creates a gradient of lattice strain at various radial locations. When doping the Mn2+ closer to the core/shell interface, the stronger lattice strain softens the vibrational frequency coupled to the 4T1?6A1 transition of Mn2+ (Mn luminescence) by ~50%. In addition, the lattice strain also increases the anharmonicity, resulting in larger local thermal expansion observed from the nearly an order larger thermal shift of the Mn luminescence compared to the Mn-doped ZnS nanocrystals without the core/shell lattice mismatch.Item Evaluation of the Procedure Used to Determine Nonlinear Soil Properties In Situ(2012-02-14) Torres, Daniel E.Soil properties (shear modulus and damping) are normally determined from laboratory tests. These tests provide both values of the shear modulus in the linear elastic range for very small levels of strain, and its variation with the level of strain. It has become more common to measure the maximum shear modulus at low levels of strain directly in the field, using geophysical techniques. The values obtained in situ can differ significantly in some cases from those determined in the laboratory, and a number of reasons and correction factors have been proposed in the literature to account for this variation. As a result, when in situ properties are available, it is normal to use these values for very low levels of strain, but still assume that the variation of the ratio G/Gmax (normalized shear modulus) with shear strain is the same as determined in the laboratory. Recently, tests have been performed using large vibrators (the Thumper and Tyrannosaurus Rex of the University of Texas at Austin) to determine soil properties in situ for larger strains, and the variation of G/Gmax obtained from these tests has been compared to that reported in the literature from lab tests. Observation indicates some generally good agreement, but also some minor variations. One must take into account, however, that in the determination of the shear modulus versus strain in the field from vibration records, a number of approximations are introduced. The objective of this work is to evaluate the accuracy of some the procedures used and to assess the validity of the simplifying assumptions which are made. For this purpose, a shear cone that would reproduce correctly the horizontal stiffness of a circular mat foundation on the surface of an elastic, homogeneous half space, was considered. The cone was discretized using both a system of lumped masses and springs and a finite difference, using second-order central difference formulation, verifying that in the linear elastic range the results were accurate. A number of studies were conducted next, increasing the level of the applied force and using nonlinear springs that would reproduce a specified G/Gmax vs. ? curve. Using a similar procedure to that used in the field tests, the shear wave velocity between hypothetical receivers and the levels of strain were determined. The resulting values of G/Gmax vs. ? were then compared with the assumed curve to assess the accuracy of the estimated values.Item Modeling the ASR Induced Strains and Cracking of Reinforced Concrete Beams(2013-05-17) Zhang, LiIn the past few decades, several researchers have studied the effects of ASR induced expansion in concrete. Several models have been proposed to model the effects of ASR in concrete. While most of these models focus on plain concrete, there is limited amount of research to model the influence of ASR expansion in reinforced concrete. Additionally, the existing models are complex and difficult to implement for practicing engineers. In this study the shortcomings with the existing models are addressed. A minimalist semi-empirical model is developed to represent the degradation of reinforced concrete due to ASR expansion. The model is validated using historical experimental data. Only two key parameters are needed to represent the expansive behavior, specifically, the maximum unreinforced concrete strain due to ASR expansion and the rise time. Mechanical properties of the reinforced concrete are also needed. From the predicted expansions, it is then shown that it is possible to model the number and spacing of cracks of a partly restrained reinforced concrete beam affected by ASR gels. The model is validated with recent experimental results on large scale reinforced concrete specimens. Predictions agree well with the observed number of cracks.Item Quantifying non-axial deformations in rat myocardium(Texas A&M University, 2005-02-17) Aghassibake, Kristina DianeWhile it is clear that myocardium responds to mechanical stimuli, it is unknown whether myocytes transduce stress or strain. It is also unknown whether myofibers maintain lateral connectivity or move freely over one another when myocardium is deformed. Due to the lack of information about the relationship between macroscopic and cellular deformations, we sought to develop an experimental method to examine myocyte deformations and to determine their degree of affinity. A set of protocols was established for specimen preparation, image acquisition, and analysis, and two experiments were performed according to these methods. Results indicate that myocyte deformations are non-affine; therefore, some cellular rearrangement must occur when myocardium is stretched.