Browsing by Subject "pulsatile flow"
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Item Arterial biomechanics and the influences of pulsatility on growth and remodeling(2009-05-15) Eberth, John FrancisArterial wall morphology depends strongly on the hemodynamic environment experienced in vivo. The mammalian heart pumps blood through rhythmic contractions forcing blood vessels to undergo cyclic, mechanical stimulation in the form of pulsatile blood pressure and flow. While it has been shown that stepwise, chronic increases in blood pressure and flow modify arterial wall thickness and diameter respectively, few studies on arterial remodeling have examined the influences that pulsatility (i.e., the range of cyclic stimuli) may have on biaxial wall morphology. We experimentally studied the biaxial behavior of carotid arteries from 8 control (CCA), 15 transgenic, and 21 mechanically altered mice using a custom designed mechanical testing device and correlated those results with hemodynamic measurements using pulsed Doppler. In this dissertation, we establish that increased pulsatile stimulation in the right carotid artery after banding (RCCA-B) has a strong affect on wall morphological parameters that peak at 2 weeks and include thickness (CCA=24.8?0.878, RCCA-B=99.0?8.43 ? m), inner diameter (CCA=530?7.36, RCCA-B=680?32.0? m), and in vivo axial stretch (CCA=1.7?0.029, RCCAB= 1.19?0.067). These modifications entail stress and the change in stress across the cardiac cycle from an arterial wall macro-structural point of view (i.e., cellular and extracellular matrix) citing increases in collagen mass fraction (CCA=0.223?0.056, RCCA-B=0.314?0.011), collagen to elastin ratio (CCA=0.708?0.152, RCCA-B=1.487?0.26), and cross-sectional cellular nuclei counts (CCA=298?58.9, RCCA-B=578?28.3 cells) at 0, 7, 10, 14, and 42 post-banding surgery. Furthermore, we study the biomechanical properties of carotid arteries from a transgenic mouse of Marfan Syndrome. This arterial disease experiences increased pulse transmission and our findings indicate that alterations occur primarily in the axial direction. The above results are all applied to a predictive biaxial model of Cauchy stress vs. strain.Item Influence of Salinous Solutions in the Pressure and Volume Modulations of the Intracranial Cavity(2012-10-19) Ceballos, MarianaFollowing a head concussion the intracranial pressure increases due to the impact, which cannot be adequately relieved because of the stiffness of the skull. Popular strategies aimed at decompressing the head consist in the administration of osmotic agents and skull removal. The mechanical properties of bone can be affected by the administration of different solutions. If the malleability of skull is influenced by the osmotic agents that are administered to the patient then the pressure and volume in the intracranial cavity can also be modified following the treatment. In this thesis research, we hypothesize that administered osmotic agents can influence the mechanical properties of the skull, which can also impact the volume the cavity can hold and subsequently the pressure in the head. This premise was tested by modifying existing mathematical models compiled through two general MATLAB codes that allow the computation of a non-symbolic differential-algebraic initial value problem. Three main features were changed in comparison to current models: the skull's influence on the pressure and volume modulation was tested (inputs were obtained from skull tested under different solutions); pulsatile flow was accounted for on the creation and movement of cerebrospinal fluid; and the input on the mechanical behavior of the cranial vessels was accounted for through previously published continuum-mechanics vessel-behavior models. To complete the model, materials and mechanical properties were obtained through laboratory experiments as well as data collection from existing literature. From our bone test we were able to conclude that there are different factors that affect the mechanical properties of bone in various degrees. There is a mild statistical correlation (p-value 0.05) between the mechanical properties of bone obtained from different regions of the skull samples (2-14mm) and the DPBS and hDPBS solutions. Additionally there is a strong statistical difference (p-value 0.05) between the mechanical properties obtained from cross head speed (0.02, 0.002, and 0.004 (mm/s)) and solution variation (DI, DPBS and hDPBS). Finally, we were able to see that there seems to be a correlation between the mechanical properties of bone, the solution treatments and hypertension; although more test need to be developed to affirm this premise since our results are preliminary.Item Pulsatile flow of a chemically-reacting non-linear fluid(Texas A&M University, 2007-09-17) Bridges, Ronald Craig, IIMany complex biological systems, such as blood and polymeric materials, can be approximated as single constituent homogeneous fluids whose properties can change because of the chemical reactions that take place. For instance, the viscosity of such fluids could change because of the chemical reactions and the flow. Here, I investigate the pulsatile flow of a chemically-reacting fluid whose viscosity depends on the concentration of a species (constituent) that is governed by a convection-reaction-diffusion equation and the velocity gradient, which can thicken or thin the fluid. I study the competition between the chemical reaction and the kinematics in determining the response of the fluid. The solutions to the equations governing the steady flow of a chemicallyreacting, shear-thinning fluid are obtained analytically. The solution for the velocity exhibits a parabolic-type profile reminiscent of the Newtonian fluid profile, if the fluids are subject to the same boundary conditions. The full equations associated with the fluid undergoing a pulsatile flow are studied numerically. A comparison of the shear-thinning/chemical-thinning fluid to the shear-thinning/chemicalthickening fluid using a new non-dimensional parameter??????the competition number (CN) shows that both the shear-thinning effects and the chemical-thinning/thickening effects play a vital role in determining the response of the fluid. For the parameter values chosen, the effects of chemical-thinning/thickening dominate the majority of the domain, while the effects due to shear-thinning are dominant only in a small region near the boundary.