Browsing by Subject "parameter estimation"
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Item Constrained expectation-maximization (EM), dynamic analysis, linear quadratic tracking, and nonlinear constrained expectation-maximation (EM) for the analysis of genetic regulatory networks and signal transduction networks(2009-05-15) Xiong, HaoDespite the immense progress made by molecular biology in cataloging andcharacterizing molecular elements of life and the success in genome sequencing, therehave not been comparable advances in the functional study of complex phenotypes.This is because isolated study of one molecule, or one gene, at a time is not enough byitself to characterize the complex interactions in organism and to explain the functionsthat arise out of these interactions. Mathematical modeling of biological systems isone way to meet the challenge.My research formulates the modeling of gene regulation as a control problem andapplies systems and control theory to the identification, analysis, and optimal controlof genetic regulatory networks. The major contribution of my work includes biologicallyconstrained estimation, dynamical analysis, and optimal control of genetic networks.In addition, parameter estimation of nonlinear models of biological networksis also studied, as a parameter estimation problem of a general nonlinear dynamicalsystem. Results demonstrate the superior predictive power of biologically constrainedstate-space models, and that genetic networks can have differential dynamic propertieswhen subjected to different environmental perturbations. Application of optimalcontrol demonstrates feasibility of regulating gene expression levels. In the difficultproblem of parameter estimation, generalized EM algorithm is deployed, and a set of explicit formula based on extended Kalman filter is derived. Application of themethod to synthetic and real world data shows promising results.Item Nonlinear Programming Approaches for Efficient Large-Scale Parameter Estimation with Applications in Epidemiology(2013-07-09) Word, Daniel PaulThe development of infectious disease models remains important to provide scientists with tools to better understand disease dynamics and develop more effective control strategies. In this work we focus on the estimation of seasonally varying transmission parameters in infectious disease models from real measles case data. We formulate both discrete-time and continuous-time models and discussed the benefits and shortcomings of both types of models. Additionally, this work demonstrates the flexibility inherent in large-scale nonlinear programming techniques and the ability of these techniques to efficiently estimate transmission parameters even in very large-scale problems. This computational efficiency and flexibility opens the door for investigating many alternative model formulations and encourages use of these techniques for estimation of larger, more complex models like those with age-dependent dynamics, more complex compartment models, and spatially distributed data. However, the size of these problems can become excessively large even for these powerful estimation techniques, and parallel estimation strategies must be explored. Two parallel decomposition approaches are presented that exploited scenario based decomposition and decomposition in time. These approaches show promise for certain types of estimation problems.Item Parameter Estimation of Complex Systems from Sparse and Noisy Data(2011-02-22) Chu, YunfeiMathematical modeling is a key component of various disciplines in science and engineering. A mathematical model which represents important behavior of a real system can be used as a substitute for the real process for many analysis and synthesis tasks. The performance of model based techniques, e.g. system analysis, computer simulation, controller design, sensor development, state filtering, product monitoring, and process optimization, is highly dependent on the quality of the model used. Therefore, it is very important to be able to develop an accurate model from available experimental data. Parameter estimation is usually formulated as an optimization problem where the parameter estimate is computed by minimizing the discrepancy between the model prediction and the experimental data. If a simple model and a large amount of data are available then the estimation problem is frequently well-posed and a small error in data fitting automatically results in an accurate model. However, this is not always the case. If the model is complex and only sparse and noisy data are available, then the estimation problem is often ill-conditioned and good data fitting does not ensure accurate model predictions. Many challenges that can often be neglected for estimation involving simple models need to be carefully considered for estimation problems involving complex models. To obtain a reliable and accurate estimate from sparse and noisy data, a set of techniques is developed by addressing the challenges encountered in estimation of complex models, including (1) model analysis and simplification which identifies the important sources of uncertainty and reduces the model complexity; (2) experimental design for collecting information-rich data by setting optimal experimental conditions; (3) regularization of estimation problem which solves the ill-conditioned large-scale optimization problem by reducing the number of parameters; (4) nonlinear estimation and filtering which fits the data by various estimation and filtering algorithms; (5) model verification by applying statistical hypothesis test to the prediction error. The developed methods are applied to different types of models ranging from models found in the process industries to biochemical networks, some of which are described by ordinary differential equations with dozens of state variables and more than a hundred parameters.Item Robust model-based fault diagnosis for chemical process systems(Texas A&M University, 2006-08-16) Rajaraman, SrinivasanFault detection and diagnosis have gained central importance in the chemical process industries over the past decade. This is due to several reasons, one of them being that copious amount of data is available from a large number of sensors in process plants. Moreover, since industrial processes operate in closed loop with appropriate output feedback to attain certain performance objectives, instrument faults have a direct effect on the overall performance of the automation system. Extracting essential information about the state of the system and processing the measurements for detecting, discriminating, and identifying abnormal readings are important tasks of a fault diagnosis system. The goal of this dissertation is to develop such fault diagnosis systems, which use limited information about the process model to robustly detect, discriminate, and reconstruct instrumentation faults. Broadly, the proposed method consists of a novel nonlinear state and parameter estimator coupled with a fault detection, discrimination, and reconstruction system. The first part of this dissertation focuses on designing fault diagnosis systems that not only perform fault detection and isolation but also estimate the shape and size of the unknown instrument faults. This notion is extended to nonlinear processes whose structure is known but the parameters of the process are a priori uncertain and bounded. Since the uncertainty in the process model and instrument fault detection interact with each other, a novel two-time scale procedure is adopted to render overall fault diagnosis. Further, some techniques to enhance the convergence properties of the proposed state and parameter estimator are presented. The remaining part of the dissertation extends the proposed model-based fault diagnosis methodology to processes for which first principles modeling is either expensive or infeasible. This is achieved by using an empirical model identification technique called subspace identification for state-space characterization of the process. Finally the proposed methodology for fault diagnosis has been applied in numerical simulations to a non-isothermal CSTR (continuous stirred tank reactor), an industrial melter process, and a debutanizer plant.