Browsing by Subject "Rats as laboratory animals"
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Item Bioavailability of selenium from different meat assessed in selenium-deficient rats(Texas Tech University, 1995-05) Wen, Hong YuanNot availableItem Lack of colon promoting carcinogenesis by beef in the rat model(Texas Tech University, 1995-12) Butler, Micah JohnThe possibility that eating red meat might cause colon cancer has received much attention by the popular press. An article in Time magazine carried the headline "Red Alert on Red Meat" (Toulexis, 1990). Additionally, a cartoon accompanying a New York Times column showed a man using a saw to cut away the section of a dining table that held a platter of steak. When articles and pictures such as these are appearing in major newspapers and magazines, it is understandable that people have become concerned or even fiightened about eating red meat and rightly so as cancer is second only to heart disease as the leading cause of death in the United States (American Cancer Society, 1992). Colorectal cancer is the third leading cancer in both men and women (Figures 1 and 2) and accounted for 11% of all cancer deaths in males and 13% in females in 1992(Anonymous, 1992). Recent epidemiological studies have implicated red meat consumption as a risk factor for colon cancer in both men and women. A recent analysis of mortality data has identified animal fat in particular as the factor most strongly correlated with the risk for colon cancer (McKeon-Eyssen et al., 1984). The association between animal fat and colon cancer was said to be largely due to red meat consumption. However, a comparative study by Kinlin (1982) of strict religious orders in Britain showed that colon cancer mortality was not lower in religious orders that consumed no meat as compared to orders that regularly consumed meat as part of their dietary intake. Furthermore, it has been difficult to separate the effects of meat as a protein source from the accompanying fat content of the diets analyzed in these studies. Very little information has been published on the dietary effects of beef consumption on experimental colon cancer, so the issue still remains controversial. Therefore, the goal of this study was to rigorously study the effects of beef as a protein source, and the effects of fat source (beef tallow and com oil) at fat levels of 5 and 20%> and their contributions as dietary factors, as either promoters that increase the risk or protectors that reduce the risk, for colon carcinogenesis.Item The effects of molybdenum and tungsten supplementations on reproductive hormones of female rats fed AIN-76A or lab chow(Texas Tech University, 1987-05) Liu, Yi-lunA previous study has demonstrated that in ppm Mo in drinking water significantly (p0.05) differences in body weight gain among groups 1-8. Estrous cycles were followed by vaginal smear. At week 20, the estrous cycle of group 3 was significantly (p<0.05) longer than that of group 4. Animals were sacrificed at the estrous phase of the cycle. Plasma estradiol concentrations ranged from 36.8 to 55.0 pa/ml for week 10, and 27.5 to 51.6 pg/ml for week 20. Estradiol levels of the AIN-76A-fed groups were generally greater than those of the Lab Chow-fed groups. The mean estradiol value of group 3 or 5 was significantly (p<0.05) higher than that of group 7 or 8, respectively. Plasma follicle stimulating-hormone (FSH) concentrations ranaed from 3.05 to 3.65 ng/ml for week 10, and 3.21 to 3.97 ng/ml for week 20. There were no significant (p>0.05) differences in FSH levels of rats fed either ATN-76A- or Lab Chow-based diets for both weeks 10 and 20. The estradiol and FSH levels appear to be influenced by the differences in the diets. No significant (p>0.05) differences in uterine weights among rats fed either AIN-76A- or Lab Chow-based diets.Item The facilitory effects of dexamethasone on the development of functional tolerance to ethanol in the rat(Texas Tech University, 1976-05) Wood, Wellington GibsonNOT AVAILABLE