Browsing by Subject "Oscillatoriaceae"
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Item Synthetic studies on a model system for the spirobicyclic ring system of oscillatoxin D(Texas Tech University, 1997-05) Jin, Xue-HuiThis thesis describes the development of some synthetic methodology applicable to the preparation of the spirobicyclic ring system of the marine natural product oscillatoxin D (1, Figure 1.1). Our goal was to find an efficient way to synthesize a major intermediate for the model compound (2) and thus to provide a guide for the subsequent synthesis of the natural product. Oscillatoxin D has shown some antileukemic activity and it might have undiscovered biological activity. It is a possible drug candidate.Item Synthetic studies related to the marine natural product oscillatoxin D(Texas Tech University, 1997-12) Kahl, Jeffrey DeanOsdllatoxin D is a nontoxic natural product found in tropical marine bluegreen algae which possesses antileukemic activity. This dissertation describes progress towards the synthesis of structurally advanced intermediates for the total synthesis of osdllatoxin D. The overall goal of this research is to test synthetic methodology aimed at streamlining the synthesis of advanced intermediates. This goal was achieved through several objectives. First, attempts were made o resolve antidpated problems with the introduction of y-lactone portion of osdllatoxin D. during the synthesis by the exploration of a novel carboxylic acid protection groups which could be removed under mild conditions. Second, attempts were made to improve the efficiency of a previously described synthesis of a major intermediate for the synthesis of osdllatoxin D. Third, an osdllatoxin D precursor bearing all of the carbon atoms of osdllatoxin D itself was prepared and used to test a hypothetical spirobicyclization reaction which would, if successful, have formed the complete central bicydic portion of osdllatoxin D.