Browsing by Subject "Mice -- Diseases"
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Item Effect of molybdenum on mammary adenocarcinoma and immune response in C57BL/6J mice(Texas Tech University, 1985-12) Davis, Lisa CarolNot availableItem Resistance to Trypanosoma brucei gambiense among inbred strains of mice(Texas Tech University, 1983-08) Perez, EncarnacionRecent human isolates of Trypanosoma brucei gambiense produce patent low grade to subpatent parasitemias in outbred mice. The purpose of this study was to determine if host genes control resistance to infection. Results of inbred mouse infections indicate that H-2^b and H-2^d haplotypes are resistant, while all H-2^k haplotype mice tested (C3H, AKR, and CE) are susceptible, with death occuring usually in the first peak. Radiation chimeras of resistant and susceptible mice (F1 and parentals), when infected, indicated that immune response genes were responsible for resistance rather than background genes. The indication that H-2^k is linked to susceptibility was proved with congenic BlO.BR/SgSn (H-2^k) mice which were found to be susceptible whereas C57LB/10 (H-2^b) were found to be resistant. Results of infections of F-^ hybrid progeny indicate resistance is dominant and is located on two or more gene loci. Survivors of first peak parasitemias were immunosuppressed and patency rates were determined. These data indicate that there is also a partial H-2 linkage to maintenance of chronic subpatent infections.Item The effect of streptomycin on colonization resistance against Pseudomonas aeruginosa in mice(Texas Tech University, 1985-08) Stein, April JaeNot availableItem The effect of streptomycin on colonization resistance against Salmonella typhimurium in mice(Texas Tech University, 1985-12) Que, John UyNot availableItem The effects of diabetes and hypervitaminosis A in genetically diabetic mice(Texas Tech University, 1985-08) Su, Nanwei ChinNot availableItem The effects of thymosin on bacterial infections in normal mice(Texas Tech University, 1982-05) Trzeciak, David RobertNormal mice treated with thymosin before a lethal challenge of bacteria show a more prolonged survival than controls. Thymosin treatment the same time as challenge offers no protection. Thymosin treatment after a lethal challenge not only does not offer protection but also causes deaths, due to the bacterial infection, to occur faster. Continuous thymosin treatment after challenge neither enhances death rates further, nor offers protection to mice treated with th3miosin at the time of challenge or mice treated with th5nnosin after challenge. However, continuous thymosin treatment after challenge does increase protection of mice treated with thymosin before challenge. The protective and suppressive effects of thymosin seem to be time dependent and antigen dependent since the suppressive effects of thymosin treatment before, at the same time, or after a sublethal dose of antigen diminish over time. However, thymosin treatment longer than 24 hours before challenge offers the protective effects. It is postulated that the effects of thymosin are regulated through helper and suppressor T cells. This is the first in vivo demonstration of protection and suppression, due to the administration of th3miosin, in normal mice against bacterial infection. The suppressive aspect of thymosin stresses an urgent need for further experimentation before thymosin is used for prophylaxis in the cattle industry.Item The elaboration of extracellular capsular polysaccharide by Klebsiella pneumoniae and its relationship to virulence(Texas Tech University, 1983-12) Domenico, PhilipNot availableItem Viral antigen expression: a measure of chemotherapeutic effect during mammary cancer treatments(Texas Tech University, 1987-05) Pyo, Suhk NeungNot available