Browsing by Subject "Marine toxins"
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Item Model studies for the total synthesis of oscillatoxin A(Texas Tech University, 1988-12) Cunningham, Raymond ThomasThis account will describe the results of research on a model study for the total synthesis of oscillatoxin A. During the course of this work, major subunits of the target molecule were assembled and protecting group schemes were devised for use during the total synthesis. In addition, a new method for the selective benzylation of 1,2-diols was developed, and a new and highly efficient method for the synthesis of 3-deoxy-L-pentoses, compounds which are useful for the synthesis of nucleoside analogues, was discovered.Item Synthetic studies on a model system for the spirobicyclic ring system of oscillatoxin D(Texas Tech University, 1997-05) Jin, Xue-HuiThis thesis describes the development of some synthetic methodology applicable to the preparation of the spirobicyclic ring system of the marine natural product oscillatoxin D (1, Figure 1.1). Our goal was to find an efficient way to synthesize a major intermediate for the model compound (2) and thus to provide a guide for the subsequent synthesis of the natural product. Oscillatoxin D has shown some antileukemic activity and it might have undiscovered biological activity. It is a possible drug candidate.