Browsing by Subject "Linkage"
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Item Genetic analysis of dilated cardiomyopathy in the great dane(2009-05-15) Herbst, Stephanie MichelleThe domestic dog, Canis familiaris, with over 450 naturally-occurring hereditary diseases, serves as a valuable model organism for study of the genetics underlying many human hereditary diseases. Approximately half of the diseases that afflict the dog are clinically very similar to various human hereditary diseases. Several cardiac diseases are in this category. Our laboratory is interested in cardiac diseases because they are common causes of death in the human and are also a widespread problem in many breeds of dog. The specific focus of my work is on understanding the genetics of dilated cardiomyopathy (DCM). DCM is a disease characterized by enlargement of the left ventricle leading to an inability of the heart to pump sufficient blood to the body. It is one of the most common cardiac diseases in the dog and has a high mortality. The Great Dane is the second most commonly affected breed. It is seen in many families of Great Danes, and this suggests that DCM has a genetic component. The mode of inheritance of DCM in the Great Dane is currently unknown, although studies have reported both autosomal recessive and autosomal dominant transmission. Many different genes cause DCM, indicating the complexity of the disease. These typically produce proteins that are involved in the sarcomere or cytoskeletal components, leading to problems with contraction or cardiac cell integrity. In order to identify causative or susceptibility genes for DCM in the Great Dane, a whole-genome linkage screen was conducted in a family of Great Danes. One candidate gene, gamma-sarcoglycan (SGCG), was identified through linkage and sequenced in affected and unaffected dogs. Sequencing data revealed no mutations in the coding regions of SGCG, most likely excluding it as a candidate gene for DCM. Continued evaluation of this gene and others, both in sequence content and additional properties such as epigenetic effects, protein structure, and interaction with other genes will increase understanding of DCM in both the dog and the human.Item High resolution linkage and association study of quantitative trait loci(Texas A&M University, 2005-11-01) Jung, JeesunAs a large number of single nucleotide polymorphisms (SNPs) and microsatellite markers are available, high resolution mapping employing multiple markers or multiple allele markers is an important step to identify quantitative trait locus (QTL) of complex human disease. For many complex diseases, quantitative phenotype values contain more information than dichotomous traits do. Much research has been done on conducting high resolution mapping using information of linkage and linkage disequilibrium. The most commonly employed approaches for mapping QTL are pedigree-based linkage analysis and population-based association analysis. As one of the methods dealing with multiple alleles markers, mixed models are developed to work out family-based association study with the information of transmitted allele and nontransmitted allele from one parent to offspring. For multiple markers, variance component models are proposed to perform association study and linkage analysis simultaneously. Linkage analysis provides suggestive linkage based on a broad chromosome region and is robust to population admixtures. One the other hand, allelic association due to linkage disequilibrium (LD) usually operates over very short genetic distance, but is affected by population stratification. Combining both approaches plays a synergistic role in overcoming their limitations and in increasing the efficiency and effectiveness of gene mapping.Item Linkage and the case of political deliberalization in Morocco(2013-05) Collins, Hope Ellen; Brownlee, Jason, 1974-; Suri, JeremiMany scholars of democratization posit that increased linkage between a hybrid regime and the West will lead to increased democratization. In Morocco during the past decade, however, authoritarianism continued to flourish despite increased linkage with both the United States and European Union. This project seeks to explain the source of this contradiction, arguing that increased linkage actually created a favorable environment for the deliberalization of Moroccan politics.Item On the parallelization of the linkage/fastlink package(Texas Tech University, 1999-12) Rai, AadityaThe remainder of this thesis is organized in the following manner. Chapter 2 gives the background informadon regarding parallelizadon concepts and tools. Chapter 3 explains profiling and analyzing a code for data dependencies. Chapter 4 presents a brief overview of Message-Passing-Interface (MPI). Chapter 5 discusses some concepts that need to be considered while achieving parallelization. Chapter 6 discusses the development ofthe parallel model and its implementadon. In Chapter 7, the experiments conducted and the results obtained are discussed at length. Chapter 8 discusses the future enhancements that could be done to extend this research work.