Browsing by Subject "Delivery"
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Item Embodied rhetoric : memory and delivery in networked writing(2010-12) Jones, John Mark, 1978-; Syverson, Margaret A., 1948-; Walker, Jeffrey; Davis, Diane; Bremen, Brian A.; Selfe, Cynthia L.Whereas the traditional rhetorical practices of memory and delivery were directly connected to the body of the speaker, I argue that when communication is embodied on digital networks, the processes underlying memory and delivery—the coordination of individual and text and the use of embodied affordances to present a text, respectively— are expressed in different ways. Resonance, or the act of bringing two structures into coordination with each other, and switching, or the act of making connections between two networks, fulfill the role of memory in digital networks, coordinating the actions of different networks. Similarly, the protocol, or the technical and cultural rules of networks, and the program, or the emergent behavior, of a network must be taken into account by writers who wish to achieve rhetorical ends. Using three case studies of network formation on the microblogging service Twitter, I show how the acts of resonance and switching, along with the protocol and program of these networks, influence network formation, the types of communication generated by networks, and how those networks are received by outsiders.Item Interactions of composite gold nanoparticles with cells and tissue : implications in clinical translation for cancer imaging and therapy(2012-12) Tam, Justina Oichi; Sokolov, Konstantin V. (Associate professor)Current methods to diagnose and treat cancer often involve expensive, time-consuming equipment and materials that may lead to unwanted side effects and may not even increase a patient’s chance of survival. Thus, for a while now, a large part of the research community has focused on developing improved methods to detect, diagnose, and treat cancer on the molecular scale. One of the most recently discovered methods of cancer therapy is targeted therapy. These targeted therapies have potential to provide a patient with a form of personalized medicine because these therapies are biological molecules that specifically target other molecules involved with a cancer’s growth. Past trials using these therapeutic molecules, however, have led to controversial results, where certain patients responded better than others to the therapy for unknown reasons. Elucidating the reason behind these mixed results can be accomplished using metal nanoparticle technologies which could provide a bright signal to monitor the path that these therapeutic molecules take in vivo as well as enhance the molecule’s efficacy. Literature has shown that presenting targeting molecules in a dense manner to their target will increase these molecules’ binding affinity. This concept has been explored here to increase binding affinity of therapeutic molecules by attaching these molecules in a dense manner on the surface of gold nanoparticles, and correlating this increased affinity with therapeutic efficacy. Additionally, gold nanoparticles provide an easy surface for molecules to be functionalized on and have shown to be effective imaging, x-ray, and photothermal therapy agents. A major roadblock to using these gold nanoparticles clinically is their non-degradability and thus potential to cause long-term negative side effects in vivo. A platform for developing biodegradable gold nanoparticles is also explored here to take advantage of the gold nanoparticles’ excellent imaging and drug delivery capabilities while still allowing them to be used safely in the long term.Item Learning to write in (networked) public: children and the delivery of writing online(2014-12) Roach, Audra Katherine; Bomer, Randy; Hoffman, Jim; Maloch, Beth; Schallert, Diane; Hodgson, JustinThis investigation explored how three children (together with parents) developed networked publics that were diverse, well-connected, and powerful in the world. It was framed in response to calls in the field to better understand the new literacies young writers develop online and outside of school, and to increase literacy educators’ attention to the role of public audiences in writing and how writing is circulated. Performative case study methodology, ethnographic methods, and digital methods were employed to track and describe the online networks of three children (ages 11-13). These focal children were actively involved with their parents in social media, and had developed widespread networks with shared interests in children’s books and book reviews (Case 1), baseball (Case 2), and helping the homeless (Case 3). The children’s online networks were conceptualized as networked publics, drawing on Warner’s (2002) notion of publics as ongoing discursive relations among strangers, and on Actor-Network Theory’s notion of networks as assemblages of diverse interests that mobilize toward a common goal (Callon, 1986) and that develop stability in relation to ongoing circulations of texts (Latour, 1986; Spinuzzi, 2008). Research questions were framed broadly around the rhetorical canon of delivery [now digital delivery (Porter, 2009)], and were concerned with how writers distributed texts online, how those texts circulated, how the networked publics become more stable and powerful, and what instabilities children and parents had to negotiate in order to accomplish all of this. Data sources included interviews with 15 children and 28 adults, and fieldnotes observations of approximately 1,700 screen-captured webpages and other online artifacts. Findings showed that the young writers and their parents initiated and sustained networked publics through distribution practices that were oriented toward building trust; their texts displayed: interest, appreciation, reliability, service, credibility, and responsiveness. Both grassroots and commercial entities circulated texts in these networks, as they were sources of the ongoing renewal these different groups all needed in order to thrive. Sources of instability included conflicts over standards of writing quality, matters of profit, and the constancy of the demand to generate new interest and writing online. Children and their parents responded to these instabilities by welcoming and negotiating heterogeneous perspectives and partnerships. Implications of the study call for further research and teaching about the art of networked public discourse and digital delivery.