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Item Oxygen Deficient Metabolism in Organs: A Link to Combustion Science(2014-12-10) Miller, Jason MathewIn an attempt to better understand and model transport of oxygen, O2, from capillaries to living cells in surrounding tissue, the group combustion (O2 deficient) concept from the field of combustion science in engineering is applied to the biological field of microvascular O2 transport from capillaries to cells immersed in interstitial fluid (IF). The conventional Krogh model represents typical biological models, considering tissue cylinder with uniform oxygen source/sink term (US) (m''', g/s/cm^3) and O2 transport from capillary on axis (COA) towards the surface; engineering models consider cylinders with O2 supplied from the surface of cylinder (COS); in addition, they present i) transport (diffusion) and ii) kinetics limited sink rates and profiles for O2. Diffusion limitation causes m''' to be proportional to local O2 concentration. Thus, the present work modifies COS engineering models for COA cases and considers only diffusion limited transport of O2 to metabolic cells from IF. O2 profiles and resulting specific metabolic rates, SMRs (W/g), are generated for four models: I) COA with oxygen dependent consumption source term (O2) (COA-O2), II) COA-US, III) COS-O2, and IV) COS-US. In order to validate the current approach, the model results are verified with the following different types of experimental data: A) If SMRs (mq W/g) are given by the allometric law, kbmk^kq=am for organ k, then COS models under limiting conditions suggest -1/3