Browsing by Subject "Carboxylic acids"
Now showing 1 - 4 of 4
Results Per Page
Sort Options
Item Immobilization of lariat ether carboxylic acids on polystyrene(Texas Tech University, 1996-08) Corley, Leo JamesThe research presented in thesis has three objectives. The first objective was to obtain a synthetic route which would allow the linkage of proton-ionizable crown ethers to commercially available, flinctionalized polystyrene. The proton-ionizable crown ethers used in this research could not be directly attached to chloromethylated polystyrene. Therefore an appropriate intermediate had to be incorporated prior to crown ether attachment. The second objective was to determine the characteristics of the base resin which allow the greatest degree of alkali metal cation binding. Structural characteristics of the base resin include the degree of crosslinking and extent of chloromethylation. These two factors could play a very significant role in the metal cation sorption ability of the various crown ether-coupled polystyrene resins. The final objective was to determine if the polymer bound proton-ionizable crown ethers maintained the metal ion binding abilities of the corresponding non-polymeric proton-ionizable crown ethers.Item Kinetic and spectroscopic isotope effects in carboxylic acids(Texas Tech University, 1981-05) Liang, Chin-kang JimNot availableItem Molecular sensing paradigms : enantioselective recognition of chiral carboxylic acids and interfacial sensing(2012-08) Joyce, Leo Anthony; Anslyn, Eric V., 1960-Determining the presence of an analyte of interest, and finding the enantiomeric purity of chiral molecules are challenging tasks. This work in molecular recognition is carried out routinely by many different researchers, including both academic as well as industrial research groups. The following dissertation presents original research directed toward two different areas of interest to the molecular recognition community: enantioselective sensing in solution, and sensing at a defined interfacial environment. This work begins with a review of the non-chromatographic ways that the enantiomeric purity of chiral carboxylic acids is determined, presented in Chapter 1. Carboxylic acids are important functional groups, both for organic synthesis as well as pharmaceutical drug development. Chapter 2 presents efforts that have been made to rapidly assess both the enantiomeric purity and identity of chiral carboxylic acids, utilizing the technique of exciton-coupled circular dichroism (ECCD). A twist is imparted on a complex, and can be correlated with the absolute configuration of the stereocenter. The enantiomeric composition can be rapidly determined. After creating the assay, the focus of the work shifted toward applying this system to new classes of analytes. Chapter 3 covers chemo- and enantioselective differentiation of [mathematical symbol]-amino acids, and continues to discuss the expansion to [mathematical symbol]-homoamino acids. Then a synthetic substrates was tested, and a series of reactions screened to determine if any enantioselectivity had been imparted by a Baeyer-Villiger oxidation. Finally, the enantiomeric composition of a biaryl atropisomer, a compound lacking a stereocenter, was determined. The signal produced from this assay is at a relatively short wavelength, and efforts were undertaken to push this signal to longer wavelength. Chapter 4 is a compendium of the lessons that were learned upon attempting to create a self-assembled sensing system. The final chapter details work that was done in collaboration with Professor Katsuhiko Ariga at the National Institute of Materials Science in Tsukuba, Japan. In this chapter, an indicator displacement assay was carried out for the first time at the air-water interface. This contribution opens the door for sensing to be carried out at defined regions, rather than free in bulk solution.Item Synthesis of lipophilic monoaza crown carboxylic acids(Texas Tech University, 1985-05) Boss, Hollis JosephNot available