Browsing by Subject "Bimodal"
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Item Combustion behaviors of bimodal aluminum size distributions in thermites(2005-05) Moore, Kevin M.; Pantoya, Michelle; Hope-Weeks, Louisa J.; Weeks, Brandon L.In recent years many studies that incorporated nano-scale or ultrafine aluminum (Al) as part of an energetic formulation demonstrated significant performance enhancement. Decreasing the fuel particle size from the micron to nanometer range alters the material¡¦s chemical and thermal-physical properties. The result is increased particle reactivity that translates to an increase in the combustion velocity and ignition sensitivity. Little is known, however, about the critical level of nano-sized fuel particles needed to enhance the performance of the energetic composite. Ignition sensitivity and combustion velocity experiments were performed using a thermite composite of Al and molybdenum trioxide (MoO3) at the theoretical maximum density (TMD) of a loose power (5% TMD) and a compressed pellet (50% TMD). A bimodal Al particle size distribution was prepared using 4 or 20 ƒÝm Al fuel particles that were replaced in 10% increments by 80 nm Al particles until the fuel was 100% 80 nm Al. These bimodal distributions allow the unique characteristics of nano-scale materials and their interactions with micron scale Al particles to be better understood.Item Combustion behaviors of bimodal aluminum sizedistributions in thermites(Texas Tech University, 2005-05) Moore, Kevin M.In recent years many studies that incorporated nano-scale or ultrafine aluminum (Al) as part of an energetic formulation demonstrated significant performance enhancement. Decreasing the fuel particle size from the micron to nanometer range alters the material¡¦s chemical and thermal-physical properties. The result is increased particle reactivity that translates to an increase in the combustion velocity and ignition sensitivity. Little is known, however, about the critical level of nano-sized fuel particles needed to enhance the performance of the energetic composite. Ignition sensitivity and combustion velocity experiments were performed using a thermite composite of Al and molybdenum trioxide (MoO3) at the theoretical maximum density (TMD) of a loose power (5% TMD) and a compressed pellet (50% TMD). A bimodal Al particle size distribution was prepared using 4 or 20 ƒÝm Al fuel particles that were replaced in 10% increments by 80 nm Al particles until the fuel was 100% 80 nm Al. These bimodal distributions allow the unique characteristics of nano-scale materials and their interactions with micron scale Al particles to be better understood.Item Mathematical modeling of Drosophila larvae crawling(2013-12) Guenther, Maximilian Norbert; Shubeita, George T.; Florin, Ernst-LudwigThe fruit fly Drosophila melanogaster is a widely used model organism for development and gene-based diseases. The flies’ genetic homology to humans, tractable genetics and straightforward manipulability make them well suitable for studies of neurologic disorders and neural degeneration. Due to the close relation between the latter and the musculoskeletal system, locomotive impairment and behavioral changes can be used diagnostically for screening and characterization of such disease models. For this purpose, advanced methods to quantify behavioral phenotypes are crucial. Given the complications arising with studying adult flies on a population level as well as the lethality of some mutations before adulthood, studies at the larval stage are more suitable. However, a quantitative mathematical model of the crawling pattern has been lacking so far. In this thesis work I show that the development of such a model and appropriate analysis techniques enable quantification of the crawling behavior and extraction of intricate details that were previously missed. In my studies, Drosophila larvae were found to follow a bimodal persistent random walk pattern, switching between an actual forward crawling phase and events where the larvae rest and reorient. This enabled quantifying the larval behavior using a set of parameters within the framework of this mathematical model. I further used the analysis I developed to study larval model systems of Alzheimer’s disease and Fragile X mental retardation, which allowed identifying differences in the modes of locomotion that were previously missed. The novel ability to sensitively and robustly quantify behavior, as described in this work, opens up the possibility to employ these methods for future drug and genetic screens. Finally, I show that starting from the analysis of a small sample of crawling larvae we can robustly simulate the mutant-specific crawling in its quantitative and qualitative aspects. Using these simulations, predictions can be made on the feasibility of experiments that may require an impractically large number of individuals to reach statistical significance, and the outcome of laborious experiments can be pre-estimated by simulations.