Browsing by Subject "Alzheimer's Disease"

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    Enhancing life with Alzheimer's : how the arts and art-making benefit persons with Alzheimer's Disease
    (2012-05) Osborn, Rachel Suniga; Adejumo, Christopher O., 1959-; Bolin, Paul E.
    The purpose of this research was to determine if incorporating individualized arts and art-making activities into the caregiving of persons with Alzheimer's Disease would help to improve their overall quality of life. To answer this question, I conducted an eight-week qualitative case study of two persons with Alzheimer's Disease. I visited the patients and their caregivers in their homes, and facilitated the incorporation of arts and art-making activities into their caregiving. These activities included painting with watercolors and acrylic paints, sewing, dancing, listening to music, collage, craftwork, storytelling, and sharing past art experiences. As a result of participating in this case study, the two persons with Alzheimer's Disease experienced increased confidence and self-esteem, a positive means of communication and social engagement, an opportunity to be validated and valued as persons with a rich life history and valuable remaining talents, and they developed new physical and mental abilities.
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    Induction and prevention of patterned neurodegeneration by amyloid precursor protein
    (2013-05) Crisp, Ashley Aaron; Pierce-Shimomura, Jonathan T.
    Alzheimer disease is characterized by the initial degeneration of a subset of cholinergic neurons. This pattern of degeneration can be triggered by overexpression of the amyloid precursor protein (APP) gene in humans. Interestingly, APP is widely expressed; it is therefore unclear why only certain cholinergic neurons are vulnerable to degeneration. We show that widespread expression of the human APP gene in the nematode Caenorhabditis elegans also induces age-dependent apoptotic degeneration of select cholinergic neurons. Identical results were obtained by overexpressing the orthologous worm gene apl-1. The pattern of neurodegeneration matched the cell-autonomous accumulation of APP protein in vulnerable neurons and could be activated cell-non-autonomously by distinct portions of APP. Vulnerability to APP accumulation and degeneration depended inversely on the level of ASK1/p38MAPK innate-immune signaling in cholinergic neurons. Lastly, we identify a compound P7C3 that blocks entrance to apoptosis caused by APP or immunodeficiency. Our results suggest that immunosenescence sculpts the cellular pattern of neurodegeneration by APP.
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    Will our final years be golden? Mortality by Alzheimer's disease in the United States
    (Texas A&M University, 2007-09-17) Davis, Mary Ann
    Alzheimer'????????s disease (AD) is the fifth leading cause of death among the elderly. This study uses National Center for Health Statistics (NCHS) Multiple Cause of Death data for the United States for the years 1998 to 2002, examining the 9.5 million death records of all decedents of age 60 and over, and determines their incidence of AD. Seven independent variables are used: age, sex, race, ethnicity, marital status, education level and whether or not they lived in a metropolitan area. This study uses logistic regression, modeling five nested models, to determine the likelihood of mortality by AD and the direction of the relationship between AD and each of the variables. A Bayesian analysis, used to determine the best fit model, found that the full model was the best fit. The major findings of the study are that the incidence of AD increases significantly with increasing age in decedents aged 60-90. However, this peaks for decedents aged 85-89. Those who survive past age 90 begin to have a lesser likelihood of mortality by AD. With the exceptions of marital status and education, the hypotheses were supported. Females are more likely to die of AD than males. NonHispanic Whites are more likely to die of AD than Hispanics and NonHispanic Blacks. There is an increased risk of dying in a nursing home if one dies of AD. Future research as outlined above is needed to learn further about this fifth leading cause of mortality of those over age 60.