Browsing by Subject "ADT"
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Item Computation of the scattering properties of nonspherical ice crystals(Texas A&M University, 2004-11-15) Zhang, ZhiboThis thesis is made up of three parts on the computation of scattering properties of nonspherical particles in the atmosphere. In the first part, a new crystal type-droxtal-is introduced to make a better representation of the shape of small ice crystals in the uppermost portions of midlatitude and tropical cirrus clouds. Scattering properties of droxtal ice crystals are investigated by using the Improved-Geometric Optic (IGO) method. At the visible wavelength, due to the presence of the hexagonal structure, all elements of the phase matrix of droxtal ice crystals share some common features with hexagonal ice crystals, such as 220 and 460 halos. In the second part of this thesis, the possibility of enhancing the performance of current Anomalous Diffraction Theory (ADT) is investigated. In conventional ADT models, integrations are usually carried out in the domain of the particle projection. By transforming the integration domain to the domain of scaled projectile length, the algorithm of conventional ADT models is enhanced. Because the distribution of scaled projectile length is independent of the particle's physical size as long as the shape remains the same, the new algorithm is especially efficient for the calculation of a large number of particles with the same shape but different sizes. Finally, in the third part, the backscattering properties of nonspherical ice crystals at the 94GHz frequency are studied by employing the Finite-Difference Time- Domain (FDTD) method. The most important factor that controls the backscattering cross section is found to be the ratio of the volume-equal radius to the maximum dimension of the ice crystal. Substantial differences in backscattering cross sections are found between horizontal orientated and randomly oriented ice crystals. An analytical formula is derived for the relationship between the ice water (IWC) content and the radar reflectivity ( e Z ). It is shown that a change to the concentration of ice crystals without any changes on the size distribution or particle habits leads only to a linear e Z IWC - relationship. The famous power law e Z IWC - relationship is the result of the shift of the peak of particle size distribution.Item Dissecting the heterogeneity of prostate cancer cells(2013-08) Liu, Xin, active 2013; Jolly, Christopher A.; Tang, Dean G.Prostate cancer (PCa) is heterogeneous containing phenotypically diverse cells. It is unclear whether these phenotypically different PCa cells are functionally distinct and possess divergent tumorigenic potential. Androgen signaling plays important roles in differentiation and survival of malignant PCa cells, and prostate specific antigen (PSA) as one of the androgen signaling target genes is used as a biomarker of AR signaling to assess tumor progression and evaluate therapeutic efficiency in clinic. Here we present evidence for discordant AR and PSA expression resulting in AR⁺/PSA⁺, AR⁺/PSA⁻, AR⁻/PSA⁻, and AR⁻/PSA⁺ PCa cells in human tumors. We also show that prostate tumor PSA mRNA levels inversely correlate with poor clinical outcomes and patient survival. By employing a lentiviral reporter system, we have fractionated bulk PCa cells into PSA⁺ and PSA⁻[superscript '/lo'] cell populations, with the former being AR⁺/PSA⁺ and the latter containing both AR⁺/PSA⁻ and AR⁻/PSA⁻ cells. The PSA⁺ and PSA⁻[superscript '/lo'] PCa cells demonstrate distinct molecular, cellular, and tumor-propagating properties. PSA⁻[superscript '/lo'] PCa cells are quiescent and refractory to stresses including androgen deprivation, exhibit high clonogenic potential, and possess long-term tumor-propagating capacity. They preferentially express stem cell genes and can undergo asymmetric cell division to generate PSA⁺ cells. Of great clinical interest, PSA⁻[superscript '/lo'] PCa cells can initiate robust tumor development and resist androgen ablation in castrated hosts, and they harbor highly tumorigenic castration resistant PCa cells. In contrast, PSA⁺ PCa cells possess more limited tumor-propagating capacity, undergo symmetric division, and are sensitive to castration. Systemic androgen levels dynamically regulate the relative abundance of PSA⁺/PSA⁻[superscript '/lo'] PCa cells in the tumors, which in turn impact the kinetics of tumor growth. Further studies reveal that the PSA⁻[superscript '/lo'] PCa cell population harbors several overlapping but nonidentical tumorigenic subsets including ALDH⁺, CD44⁺, and [alpha]2[beta]1⁺ cells and ALDH⁺CD44⁺[alpha]2[beta]1⁺ can further enrich castration resistant PCa cells. These observations together suggest that heterogeneous PCa cells are organized as a tumorigenic hierarchy. Our results have important implications in understanding how different subpopulations of PCa cells manifest differential responses to current androgen deprivation therapy (ADT).