Unrestricted.2016-11-142011-05-232016-11-142011-05http://hdl.handle.net/2346/ETD-TTU-2011-05-1351The synthesis and characterization of chiral and achiral N-phosphonyl imines has been achieved. Chiral N-phosphonyl imines have been successfully utilized in the asymmetric addition of diethyl phosphate and cyanide to obtain α-amino phosphonates and α-amino nitriles respectively; excellent yields and diastereomeric ratios have been obtained. Achiral N-phosphonyl imines have been effectively used in the asymmetric addition of cyanide in an enantioselective fashion by using a chiral amino acid, a chiral amino alcohol or chiral BINOL derivatives. All products can be purified by GAP (Group-Assistant-Purification) chemistry. In addition, the use of microwave irradiation for multicomponent domino reactions has been achieved. Quinazolines were obtained from aromatic aldehydes, 2-cyanoacetamide and cyclopentanone. Spirocyclic compounds have also been obtained from isoxazoles, aromatic aldehydes and Meldrum’s acid. The formation of various chiral centers was obtained in a regioselective manner for both reactions.application/pdfengPhosphonyl imine chemistryGAP ChemistryMulticomponent domino reactionsMicrowave irradiationChiral auxiliaryChiral catalystThesis