Magnus, Philip D.2014-02-212017-05-112017-05-112009-08August 200http://hdl.handle.net/2152/23286textHerein is described our synthetic studies towards the synthesis of secu'amamine A, a member of the Securinega alkaloids. The first chapter describes the isolation, biological significance and previous synthesis of secu'amamine A. Chapter 2 discusses our proposed biogenetic origin of secu'amamine A from allosecurinine and the model studies to support the intermediacy of the putative aziridinium ion. Chapter 3 discusses our synthetic approach to the formation of rings A and C, as well as investigations on the regioselective functionalization of 1,2-dihydropyridines. Chapter 4 discusses the synthesis of ring D from ring D' and the transformations of our advanced intermediates with different carbamate protective groups. Chapter 5 consists of experimental details and characterization data for all new compounds.application/pdfSecu'amamine ASecurinegaAlkaloidsSecu'amamineSecurinineAllosecurinineAziridinium ionAziridinium intermediate1,2-dihydropyridineBiogenetic originThesis2014-02-21