Sessler, Jonathan L.Ellington, Andrew2016-07-192018-01-222016-07-192018-01-222014-12December 2http://hdl.handle.net/2152/39138This thesis describes the synthesis of several strapped pyrithione compounds and their antiproliferative effects in A549 and PC3 cells. Herein, additional structure-function studies reveal effects of strap length on antiproliferative activity. A dependence on adjacent thiol and N-oxide groups within the pyrithione cores also suggests a cation dependent mechanism of action. The ability to perturb intracellular levels of Na+, K+, Zn2+, and ATP are also described.application/pdfenCancerPyrithioneAnti-cancerChelatorThesis2016-07-19