Browsing University of Texas Southwestern Medical Center by Title
Now showing items 1-20 of 922
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1,3-Dipolar Cycloaddition of Electron-rich Alkynes and Optically Active Allenes in Asymmetric Catalysis
(2009-09-04)This dissertation includes two parts. The first part focuses on two 1,3-dipolar cycloadditions of electron-rich alkynes. Chapter one describes a copper-promoted cycloaddition reaction of acetylides with diazocarbonyl ... -
3 Tesla Magnetic Resonance Imaging of Hippocampal Asymmetry: Results from the Dallas Heart Study
(2013-08-01)Keywords: hippocampal asymmetry, hippocampus freesurfer fsl, mesial temporal sclerosis, temporal lobe ipilepsy Background Asymmetry of the hippocampus is regarded as an important clinical finding but limited data on ... -
3D Animated Video Series for Patient Education of Pelvic Organ Prolapse and Sacrocolpopexy Surgery
(2013-01-17)The objective of this video series was to present a comprehensive three-dimensional patient education video series that described basic female pelvic anatomy, types of pelvic organ prolapse, basic procedural steps for a ... -
4D Study of Thoracic Cancer Radiation Treatment
(2007-05-22)Respiratory motion causes an added uncertainty in the radiation treatment of thoracic malignancies due to an increase in the normal tissue irradiated and an uncertainty in the radiation coverage of the tumor. This results ... -
Aberrant DNA Methylation and Cancer: A Global Analysis of Promoter Hypermethylation in Human Lung Cancers
(2006-12-20)Tumor-acquired alterations in DNA methylation include both genome-wide hypomethylation and locus specific hypermethylation. Global loss of DNA methylation destabilizes chromatin architecture, augments genomic instability, ... -
Acanthamoeba spp. Secrete a Mannose-induced Protein That Correlates With Ability to Cause Acanthamoeba Keratitis
(2004-01-14)Acanthamoeba spp. are ubiquitously distributed in the environment. The trophozoite form can infect the cornea and cause sight-threatening corneal inflammation known as Acanthamoeba keratitis. The pathogenic cascade of ... -
Access to Care Factors Connected to Age at Evaluation for Children Assessed for Autism Spectrum Disorders
(2012-07-20)The early identification of children with an autism spectrum disorder (ASD) is important for intervention programs to take place. The goal of this study was to examine the combination of several sociodemographic factors ... -
Acetaminophen Dose Does Not Predict Outcome in Acetaminophen-Induced Acute Liver Failure
(2011-10-03)Acetaminophen is a dose-dependent toxin. Prognosis in severe acute liver injury is related presumably in part to the dose ingested. We sought to assess the value of acetaminophen dosing information in patients with acute ... -
Activation of early neural progenitors is required for traumatic brain injury-induced hippocampal neurogenes
(2008-09-19)Traumatic brain injury (TBI) is the most common form of acquired brain injury in both children and adults in the United States. TBI causes neuronal loss and results in a variety of neurological impairments and deficits ... -
Activity-Dependent Regulation of Inhibition from Different Inhibitory Subtypes
(2007-08-08)Neuronal activity, in the form of action potential firing, is critical in the maturation and maintenance of neocortical circuitry. A negative feedback mechanism by which neuronal circuits adapt to changing levels of average ... -
Acute Treatment Outcomes and Family Functioning of Children and Adolescents Diagnosed with Anorexia Nervosa
(2006-08-11)Recent studies have suggested that there is a relationship between treatment outcomes and baseline factors related to family functioning and specific eating disorder symptoms. However, these relationships have not been ... -
Acyloxyacyl Hydrolase: Studies on Its Regulation and Function in Mus Musculus
(2004-01-14)Acyloxyacyl hydrolase (AOAH) is an enzyme that detoxifies Gram-negative bacterial lipopolysaccharides (LPS) by selectively removing secondary acyl chains from the lipid A moiety. Originally found in neutrophils, it is also ... -
The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
(2007-05-22)Up-regulation of cAMP/PKA signaling by drugs of abuse may contribute to escalation and relapse, possibly by differentially altering dopamine receptor-responsiveness in the mesolimbic dopamine system. To investigate this ... -
Additional Validation of the Pain Medication Questionnaire in a Sample of Patients with Chronic Pain
(2009-09-04)The present study represents an initial stage in the formal attempt to aid in developing a psychometrically sound, self-report screen tool used for assessing potential pain medication misuse risk. This study follows ... -
ADHD Subtypes and the Convergent Validity of the Brief Three-Factor Approach and D-KEFS Color-Word Interference Test
(2014-05-06)Deficits in executive functioning (EF) often translate to significant impairment in real-life situations. EF can be assessed by performance-based tests or through the use of behavior ratings; however, most research has ... -
Adherence as a Mediating Variable Between Depression and Health Outcomes in Adolescents with Type 1 Diabetes
(2013-12-30)Adolescence is often a time of diabetes mismanagement and poor metabolic control in adolescents with type 1 diabetes. Symptoms of depression are related to poor metabolic control, but the mechanism that links them is under ... -
Adipose-Derived Stromal Cells Contribute To Spinal Cord Repair But Are Not Neural-Crest Derived Stem Cells
(2007-08-08)Neurodegeneration and injury to the nervous system are characterized by a loss of neurons - and often supporting glia - at the afflicted site. Neurons of the adult CNS are terminally differentiated, non-mitotic cells that ... -
Advanced Array Imaging for Breast and Prostate Sonography
(2010-05-14)[Abstract from Thesis “Introduction.”] In conventional medical ultrasound such as B-mode imaging, the amplitude of the backscattered ultrasound pulse is used to image tissues along a fixed beam direction1. This imaging ... -
Alexithymia in Adolescents with Inflammatory Bowel Disease
(2013-01-17)Adolescents with inflammatory bowel disease exhibit increased psychosocial problems, such as higher rates of depressive symptoms; however, the relationship between psychological factors and health outcomes remains relatively ... -
Algorithmic Developments for Sequence Analysis, Structure Modeling and Functional Prediction of Proteins
(2006-12-20)Sequence, structure and function, being the three most important properties of proteins, are interrelated through homology relationships. In this post-genome era, we are equipped with abundant sequence information. Homology ...