Browsing University of Texas Medical Branch by Title
Now showing items 262-281 of 285
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Structural studies of the YedU stress protein
(2004-11-12)The knowledge of stress proteins is important for understanding stress response, pathology of a broad set of diseases, and the development of therapeutics. The Escherichia coli YedU stress protein, also known as Hsp31, ... -
A structure-function analysis of the marine toxin neodysiherbaine and its synthetic analogs on kainate receptors
(2008-08-15)Kainate receptor antagonists show efficacy in multiple animal models of neuropathologies, including pain and epilepsy. These receptors are selectively targeted by a number of natural and synthetic ligands. The goals of ... -
Structure-function of Dengue 2 virus envelope protein domain III with neutralizing antibodies
(2008-08-28)Dengue is the most significant arboviral disease affecting humans and therefore it is essential to produce effective countermeasures against this disease in the form of vaccines and antiviral drugs. Neutralizing antibodies ... -
Strucutre-function studies of the venezuelan equine encephalitis virus 5'UTR promoter element and its role in attenuation of the virus
(2009-05-19)RNA structural elements play critical roles in several viral processes. An \r\nattempt to elucidate the role of one such RNA structural element encoded by the 5’ \r\nUntranslated Region (5’UTR), in regulating virus replication ... -
Studies on Fortilin-Prohibitin Interaction
(2013-06-03)Abstract: Apoptosis, programmed cell death, is a tightly regulated process that occurs in development, in tissue maintenance and turnover, and in regulating the immune system. Alterations in apoptosis regulation is known ... -
Substrate specificity and functional characterization of sodium/dicarboxylate cotransporters
(2006-05-05)Transport of dicarboxylates across the plasma membrane is mediated by the Na+/dicarboxylate cotransporters (NaDCs) belonging to the SLC13 gene family. These transporters play important roles in the homeostasis of ... -
Survey of obesity-related programs in Galveston County Public Schools: A pilot study
(2008-04-21)Childhood and adolescent obesity has developed into a major public health concern in the United States. The overweight and obesity rates of our children continue to rise and have been increasing dramatically for over 40 ... -
Sylvatic dengue: evolution, emergence, and impact on human health
(2007-10-24)Dengue viruses (DENV) are the most important arboviral pathogens in tropical and subtropical regions throughout the world. Transmission includes a sylvatic, enzootic cycle between nonhuman primates and arboreal mosquitoes ... -
Taser subjects: Identification of high-risk individuals
(2008-04-21)Taser® devices are used by many police forces as a nonlethal means of subduing individuals. These devices use conducted electrical energy to cause neuromuscular incapacitation. Tasers have been associated with adverse ... -
The Role of Sacsin as a Molecular Chaperone
(2013-06-03)The central pathological finding in neurodegenerative disease is loss of neurons. In many disorders, this loss of neurons appears to be related to protein misfolding, comprising a large public health burden. For example, ... -
A thermodynamic definition of protein folds
(2008-05-01)Modern techniques in structural biology, like homology modeling, protein threading, protein fold classification, and homology detection have proven extremely useful. For example, they have provided us with evolutionary ... -
Towards the rational design of mechanical proteins
(2009-04-23)The biological functions of proteins have long been studied in a manner that has deprived us of a basic mode of inquiry: physical manipulation. In recent years theoretical and technological advances have made possible ... -
Tuberculosis: Epidemiology, Diagnosis, Treatment, Prevention and Control in the United States and Worldwide
(2013-06-03)TB is one of the most common infectious diseases worldwide. Approximately one-third of the world’s population is infected with TB. In 2011, there are about 9 million new infections and almost 1.4 million deaths. Furthermore, ... -
Tuberculosis: standards and resources for quality improvement in resource limited settings
(2010-01-01)Tuberculosis is a significant problem, infecting nearly 9 million new patients per year and killing about 2 million a year. The fight to eradicate TB is located primarily in countries that are resource poor and ... -
Tyrosine nitration and altered protein pool levels of glyceraldehyde-3-phosphate dehydrogenase following ischemia/reperfusion: The influence of aging in glycolytic skeletal muscle
(2009-06-09)Aging and skeletal muscle ischemia/reperfusion (I/R) injury both lead to skeletal\r\nmuscle dysfunction, evidenced by decreased contractile force generation, particularly in\r\nglycolytic muscle. The deficits in I/R are ... -
Understanding the assembly of simple ssRNA virus nucleocapsids
(2010-08-28)The assembly of simple ssRNA viruses from the initial interactions critical for nucleocapsid formation until the morphogenesis which occurs at each maturation stage of the virus’s “life” can entail a wide range of possibilities ... -
Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
(2005-06-15)The inducible costimulatory molecule (ICOS) is a relatively new member of the CD28 family of costimulatory molecules. For the first time, we have characterized the role of ICOS/ICOSL costimulation in experimental autoimmune ... -
Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners
(2005-11-07)Repeated administration of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) induces “behavioral sensitization,” an enhancement of its behavioral effects. The molecular changes underlying behavioral sensitization may ... -
Use of surface enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF MS) to study protein expression in a rat model of cocaine withdrawal
(2005-07-22)SELDI-TOF MS is an analytical technology that combines chromatography and mass spectrometry. It is being exploited for the measurement of numerous proteins in serum, less often in organ tissue (rarely in brain). We applied ... -
UTMB's History of Care for the Indigent
(2008-02-24)Today, 24.1 percent of Texas inhabitants have no health insurance, by choice or happenstance; medical inflation is approximately 6 percent annually; and federal support for indigent health care is eroding in the face of a ...