Browsing University of Texas Medical Branch by Title
Now showing items 270-285 of 285
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Taser subjects: Identification of high-risk individuals
(2008-04-21)Taser® devices are used by many police forces as a nonlethal means of subduing individuals. These devices use conducted electrical energy to cause neuromuscular incapacitation. Tasers have been associated with adverse ... -
The Role of Sacsin as a Molecular Chaperone
(2013-06-03)The central pathological finding in neurodegenerative disease is loss of neurons. In many disorders, this loss of neurons appears to be related to protein misfolding, comprising a large public health burden. For example, ... -
A thermodynamic definition of protein folds
(2008-05-01)Modern techniques in structural biology, like homology modeling, protein threading, protein fold classification, and homology detection have proven extremely useful. For example, they have provided us with evolutionary ... -
Towards the rational design of mechanical proteins
(2009-04-23)The biological functions of proteins have long been studied in a manner that has deprived us of a basic mode of inquiry: physical manipulation. In recent years theoretical and technological advances have made possible ... -
Tuberculosis: Epidemiology, Diagnosis, Treatment, Prevention and Control in the United States and Worldwide
(2013-06-03)TB is one of the most common infectious diseases worldwide. Approximately one-third of the world’s population is infected with TB. In 2011, there are about 9 million new infections and almost 1.4 million deaths. Furthermore, ... -
Tuberculosis: standards and resources for quality improvement in resource limited settings
(2010-01-01)Tuberculosis is a significant problem, infecting nearly 9 million new patients per year and killing about 2 million a year. The fight to eradicate TB is located primarily in countries that are resource poor and ... -
Tyrosine nitration and altered protein pool levels of glyceraldehyde-3-phosphate dehydrogenase following ischemia/reperfusion: The influence of aging in glycolytic skeletal muscle
(2009-06-09)Aging and skeletal muscle ischemia/reperfusion (I/R) injury both lead to skeletal\r\nmuscle dysfunction, evidenced by decreased contractile force generation, particularly in\r\nglycolytic muscle. The deficits in I/R are ... -
Understanding the assembly of simple ssRNA virus nucleocapsids
(2010-08-28)The assembly of simple ssRNA viruses from the initial interactions critical for nucleocapsid formation until the morphogenesis which occurs at each maturation stage of the virus’s “life” can entail a wide range of possibilities ... -
Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
(2005-06-15)The inducible costimulatory molecule (ICOS) is a relatively new member of the CD28 family of costimulatory molecules. For the first time, we have characterized the role of ICOS/ICOSL costimulation in experimental autoimmune ... -
Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners
(2005-11-07)Repeated administration of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) induces “behavioral sensitization,” an enhancement of its behavioral effects. The molecular changes underlying behavioral sensitization may ... -
Use of surface enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF MS) to study protein expression in a rat model of cocaine withdrawal
(2005-07-22)SELDI-TOF MS is an analytical technology that combines chromatography and mass spectrometry. It is being exploited for the measurement of numerous proteins in serum, less often in organ tissue (rarely in brain). We applied ... -
UTMB's History of Care for the Indigent
(2008-02-24)Today, 24.1 percent of Texas inhabitants have no health insurance, by choice or happenstance; medical inflation is approximately 6 percent annually; and federal support for indigent health care is eroding in the face of a ... -
Virulence associated functions and vaccine potential of the burkholderia mallei type three secretion effector BopA
(2008-08-15)The detailed mechanism(s) of Burkholderia mallei pathogenesis is virtually unknown, with the production of a polysaccharide capsule and presence of secretion systems as the only known mechanisms associated with virulence. ... -
West Nile virus versus the host cell: Identification of host factors that modulate infection
(2008-08-27)There are two competing aspects of virus-host interactions: (i) those that enhance virus transmission and (ii) those that reduce or prevent viral replication and transmission. Each of these types of interactions is critical ... -
Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
(2009-03-06)A major yet unsolved quest in treating traumatic brain injury (TBI) is the understanding of the secondary cellular injury that contributes to cell death. Whether zinc ions are toxic or protective in TBI is controversial. ... -
Zinc-mediated cell death in the hippocampus following experimental traumatic brain injury
(2008-07-15)Traumatic brain injury (TBI) is a leading cause of morbidity and mortality of Americans both in the 15-25 age range and in the elderly population. Hippocampal neuronal damage is a key feature of experimental fluid percussion ...