Browsing Texas Tech University by Author "MacDonald, Clinton C."
Now showing items 1-7 of 7
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Characterization and function of cks2-a cyclin dependent kinase regulatory subunit-during spermatogenesis
Attaya, Ebtesam Nabil (2005-05)Cell division is controlled by cyclin dependent kinases (CDKs) that are activated to phosphorylate various downstream targets. My goal was to study the CDKs and interacting proteins that control meiosis. CDK2beta, the ... -
Characterization and function of cks2-a cyclin dependent kinase regulatory subunit-during spermatogenesis
Attaya, Ebtesam Nabil (Texas Tech University, 2005-05)Cell division is controlled by cyclin dependent kinases (CDKs) that are activated to phosphorylate various downstream targets. My goal was to study the CDKs and interacting proteins that control meiosis. CDK2beta, the ... -
Characterization of XCdc7/Dbf4 and Cdc7/Drf1 in DNA replication initiation
Hirsch, Rachael (Texas Tech University, 2006-12)Complete and accurate DNA replication is essential for proper cell division and thus the genetic integrity of all organisms. Several mechanisms regulate the process of DNA replication particularly during the initiation ... -
Domains of CstF-64 and their functions in polyadenylation
Hockert, John Andrew (Texas Tech University, 2007-12)Polyadenylation, a critical process for expression of most eukaryotic genes, requires multiple protein factors and pre-mRNA elements. However, the essential nature of polyadenylation proteins precludes in vivo determination ... -
Functional characterization of a nervous system-expressed isoform of the CstF-64 polyadenylation protein
Shankarling, Ganesh S. (Texas Tech University, 2009-05)Alternative splicing and polyadenylation are important mechanisms for creating the proteomic diversity necessary for the nervous system to fulfill its specialized functions. I discovered an evolutionarily conserved family ... -
Genetic manipulation of P-glycoprotein provides new tools for biophysical studies of the ABC multidrug transport mechanism
Swartz, Douglas (2012-12)P-glycoprotein (Pgp) is an ATP Binding Cassette (ABC) transporter that functions as a multidrug efflux pump, and contributes to multidrug resistance in cancer and other diseases. Pgp operates through a poorly understood ... -
Multiple mechanisms of polyadenylation site choice in male germ cells
McMahon, K. Wyatt (Texas Tech University, 2007-05)Polyadenylation, the process involved in the formation of the poly(A) tail at the 3¡¬ end of eukaryotic messenger RNAs (mRNAs), has been traditionally described as a two step process. However, the first and best understood ...