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dc.contributor.advisorKrische, Michael J.en
dc.contributor.committeeMemberAnslyn, Eric Ven
dc.contributor.committeeMemberDong, Guangbinen
dc.contributor.committeeMemberKeatinge-Clay, Adrian Ten
dc.contributor.committeeMemberKerwin, Sean Men
dc.creatorSam, Brannonen 2015en
dc.description.abstractOne of the more formidable challenges in the synthesis of complex organic molecules remains the efficient formation of carbon-carbon bonds. The development of a broad class of reactions to achieve this goal involves the addition of carbon based nucleophiles to carbonyl and imine compounds. Until recently, classical approaches to carbon-carbon bond formation generally required the use of stoichiometric pre-formed organometallic reagents to serve as nucleophiles, which translate into stoichiometric organometallic byproducts. In an effort to minimize nucleophile pre-activation and byproduct formation, our lab has developed efficient methods for carbonyl and imine additions via in situ formation of alkyl metal nucleophiles from π-unsaturates. The research reported herein describes our advances in an assortment of transition metal-catalyzed carbon-carbon bond forming reactions mediated by transfer hydrogenation, including regioselective hydrohydroxymethylation, hydrohydroxyfluoroalkylation, and hydroaminomethylation. Additionally, the investigation of regioselective carbonyl vinylation is reported.en
dc.subjectHomogenous catalysisen
dc.subjectC-C couplingsen
dc.titleTransition metal catalyzed regioselective carbon-carbon bond formation mediated by transfer hydrogenationen

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