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dc.contributor.advisorMagnus, Philip D.en
dc.creatorAllison, Jeffrey Corbinen
dc.date.accessioned2011-06-23T20:22:44Zen
dc.date.accessioned2017-05-11T22:22:26Z
dc.date.available2011-06-23T20:22:44Zen
dc.date.available2017-05-11T22:22:26Z
dc.date.issued2003-05en
dc.identifier.urihttp://hdl.handle.net/2152/11929en
dc.descriptiontexten
dc.description.abstractThis dissertation is devoted to our synthetic work focused at the total synthesis of the natural product Taxol. Chapter 1 serves as an introduction to the Taxane family with a discussion on related anti-tumor agents, previous synthetic work, and our retrosynthetic analysis. Chapter 2 describes our approach to synthesizing a Taxol A-ring fragment using classical Diels-Alder chemistry. Chapter 3 details our implementation of a modified Birch reduction to afford a Taxol C-ring fragment. In Chapter 4, our exploration of [2,3] sigmatropic rearrangements with Taxane ether and thioether derivatives is presented. Chapter 5 examines our advances in the [2,3] rearrangements using Taxane amine derivatives. Finally, Chapter 6 contains a description of the experiments performed along with the relevant analytical data.
dc.format.mediumelectronicen
dc.language.isoengen
dc.rightsCopyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.subjectPaclitaxel--Synthesisen
dc.titleStudies directed towards the total synthesis of the natural product Taxolen
dc.description.departmentChemistryen
dc.rights.restrictionRestricteden


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