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dc.contributor.advisorNiederkorn, Jerryen
dc.creatorHurt, Michael Allenen
dc.date.accessioned2010-07-12T17:32:30Zen
dc.date.accessioned2014-02-19T22:01:18Z
dc.date.available2010-07-12T17:32:30Zen
dc.date.available2014-02-19T22:01:18Z
dc.date.issued2004-01-14en
dc.identifier.otheren
dc.identifier.urihttp://hdl.handle.net/2152.5/312en
dc.description.abstractAcanthamoeba spp. are ubiquitously distributed in the environment. The trophozoite form can infect the cornea and cause sight-threatening corneal inflammation known as Acanthamoeba keratitis. The pathogenic cascade of Acanthamoeba keratitis begins when Acanthamoebae bind to mannose expressed on traumatized corneas. Published reports indicate that mannose is upregulated on the corneal surface during wound healing. Experiments in laboratory animals have shown that corneal abrasion prior to infection is essential for generating Acanthamoeba keratitis. Furthermore, supernatants from Acanthamoebaen
dc.format.mediumElectronicen
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.subjectEye Infections, Parasiticen
dc.subjectAcanthamoeba Keratitisen
dc.subjectProtozoan Proteinsen
dc.titleAcanthamoeba spp. Secrete a Mannose-induced Protein That Correlates With Ability to Cause Acanthamoeba Keratitisen
dc.type.genredissertationen
dc.type.materialTexten
thesis.degree.nameDoctor of Philosophyen
thesis.degree.levelPh.D.en
thesis.degree.disciplineen
thesis.degree.grantorGraduate School of Biomedical Sciencesen
thesis.degree.departmenten
dc.format.digitalOriginborn digitalen
thesis.date.available2005-01-14en


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