Show simple item record

dc.contributor.advisorC. Glen Mayhall M.D.en_US
dc.contributor.committeeMemberNorbert J. Roberts Jr. M.D.en_US
dc.contributor.committeeMemberChristine M. Arcari PhDen_US
dc.creatorAngela Lois Hewletten_US
dc.date.accessioned2011-12-20T16:04:18Z
dc.date.accessioned2014-02-19T22:04:55Z
dc.date.available2010-09-28en_US
dc.date.available2011-12-20T16:04:18Z
dc.date.available2014-02-19T22:04:55Z
dc.date.created2009-03-13en_US
dc.date.issued2009-05-02en_US
dc.identifier.otheretd-03132009-100033en_US
dc.identifier.urihttp://hdl.handle.net/2152.3/43
dc.description.abstractBACKGROUND: Few data are available on MRSA colonization in day care. We performed a study in a medical university child care center to determine the epidemiology of MRSA in this population. \r\n\r\nMETHODS: A cross sectional study was done involving 104 day care attendees and 32 adult employees. Swab samples were taken from children, employees, the environment, and household contacts of participants found to be colonized with MRSA. Parents and employees completed questionnaires. Swabs were incubated in broth, then plated on agar and identified as MRSA by routine methods. Isolates were analyzed for relatedness using molecular typing. Statistical analysis was performed. \r\n\r\nRESULTS: The prevalence of MRSA in the children was 6.73%. One employee (3.13%) was colonized with MRSA. Cultures of 6 of 17 (35.3%) family members of participants positive for MRSA yielded MRSA. MRSA was recovered from 4 environmental samples. On molecular typing, many of the MRSA isolates were indistinguishable. Univariate analysis identified macrolide antibiotics (p=0.004), asthma medications (p=0.036), other medications (p=0.036), and previous surgery (p=0.022) as risk factors. On multivariable analysis, receipt of macrolide antibiotics (p=0.002; OR 39.6; 95% CI 3.4-651.4), and receipt of asthma medications (p=0.024; OR 26.9; 95% CI 1.5-500.7) remained related to MRSA colonization. \r\n\r\nCONCLUSIONS: There was a low prevalence of MRSA colonization in children and employees in the child care center. A higher prevalence of colonization was found among household contacts of children and employees colonized with MRSA. Molecular typing showed that transmission of MRSA likely occurred in the child care center. Macrolide antibiotics may increase the risk of MRSA colonization in this population.\r\nen_US
dc.format.mediumelectronicen_US
dc.language.isoengen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the TDL web site by The University of Texas Medical Branch at Galveston was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.subjectStaphylococcus aureusen_US
dc.subjectMRSAen_US
dc.subjectmethicillin-resistant Staphylococcus aureusen_US
dc.subjectday careen_US
dc.subjectchild careen_US
dc.titleEpidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in a university medical center day care facilityen_US
dc.type.genrethesisen_US
dc.type.materialtexten_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelMasteren_US
thesis.degree.grantorThe University of Texas Medical Branchen_US
thesis.degree.departmentPreventative Medicine and Community Healthen_US


Files in this item

FilesSizeFormatView
FinalThesis3.doc372.7Kbapplication/mswordView/Open
FinalThesiscover1.doc36.86Kbapplication/mswordView/Open
FinalThesisFrontMatter2.doc32.76Kbapplication/mswordView/Open

This item appears in the following Collection(s)

Show simple item record