Automated Quantification Of White Matter Hyperintensity Burden Using Mprage And Flair Images From A Large Population

White Matter Hyperintensity(WMH) burden, as observed in T2 and proton weighted MR images, is associated with several health factors such as decreased cognitive ability, hypertension, diabetes and cerebrovascular disease. An algorithm was developed to automatically estimate WMH burden from pairs of MPRAGE and FLAIR images which is robust and requires essentially no operator involvement. The WMH burden estimation generated by this fully automated algorithm has been shown to correlate well with known risk factors for WMH burden.