Browsing by Subject "Motor unit"

Now showing 1 - 4 of 4
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    Motor unit firing patterns during sustained ischemic submaximal contractions
    (2010-12) Shah, Kena Pankajkumar; Griffin, Lisa; Abraham, Lawrence D.
    The aim of this study was to determine motor unit firing patterns during ischemic versus non-ischemic sustained submaximal isometric contractions of the tibialis anterior muscle. 10 healthy adults attended two experimental sessions approximately 48 hours apart. Both sessions were identical except that the fatigue task in one was performed with a pressure cuff placed above the knee and inflated to 180 mm Hg. Three 5s maximum voluntary contractions (MVCs) were performed prior to and after the fatigue task. Each participant held a target force of 20% MVC until endurance time (peak-to-peak tremor amplitude exceeded 5% MVC). Single motor unit firing rates (11 non ischemic, 9 ischemic) were recorded with intramuscular fine wire electrodes. Mean interspike intervals over 5s time bins were calculated at every 5% endurance time. The endurance time for the ischemic (3.7 ± 0.58 min) fatigue task was significantly (p<0.001) shorter than the non-ischemic (9.5 ± 0.57 min) task. There was no significant difference in mean motor unit firing rates between the two conditions (p=0.883). Within both tests, there was a significant decline in firing rate (ischemic initial: 12.95 ± 0.71 Hz, minimum: 11.41 ± 0.81 Hz, p=0.023; non-ischemic initial: 13.13 ± 0.87 Hz, minimum: 11.15 ± 0.48 Hz, p=0.012). The time to minimum firing rate was significantly (p<0.001) less in the ischemic (1.29 ± 0.2 min) compared to non-ischemic (3.14 ± 0.23 min) condition. Muscle ischemia significantly reduced endurance time and the time to minimum firing rate. However, there were no differences in average motor unit firing rates between the two conditions across the relative phases of endurance time.
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    Muscle force potentiation and motor unit firing patterns during fatigue : effects of muscular endurance training
    (2010-05) Mettler, Joni Ann; Griffin, Lisa; Abraham, Larry; Farrar, Roger; Jones, Theresa; Spirduso, Waneen
    Muscular fatigue limits athletic performance as well as activities of daily living that require repetitive or sustained contractile activity. The decrease in force output or inability to maintain a given force level during fatigue occurs as the result of neural and muscle physiological factors. In contrast to muscle fatigue, potentiation is an increase in muscle force following voluntary muscle activity. The simultaneously occurring processes of potentiation and fatigue influence force output. The aims of this research were to investigate parameters used to potentiate muscle via electrical stimulation and voluntary contraction, and to better understand how muscle force is sustained, we studied single motor unit firing patterns and force potentiation following muscular endurance training. In study 1, electrical stimulation trains matched for pulse number of various frequencies and of increasing pulse number at a given frequency were administered to determine the effects of these stimulation parameters and of the force-time integral (FTI) produced during the train on potentiation magnitude. No difference in potentiation magnitude was found across trains of matched pulse number for frequencies of 15, 25, 30 and 50 Hz. Potentiation increased as pulse number increased and there was a positive correlation between potentiation and the FTI. In study 2, we measured maximal potentiation following conditioning contractions (CC) of 25%, 50% and 100% maximal voluntary contraction (MVC) and during a 25% MVC fatigue task, pre-post 8 weeks of muscular endurance training. Results showed significant potentiation for all CC intensities. Potentiation increased as CC intensity increased and CC duration required to achieve maximal potentiation decreased as CC intensity increased. Muscular endurance training resulted in increased maximal potentiation, and potentiation was greater during the fatigue task after training. Potentiation was also correlated to endurance time. In study 3, the effects of muscular endurance training on motor unit firing rates were investigated. There was a small increase in mean motor unit firing rates during the course of the fatigue task after training. This research contributes to our understanding of muscular force production and muscular endurance. The findings suggest that motor unit firing frequency and force potentiation may contribute to enhanced muscular endurance.
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    Nervous system differences between the sexes and across the menstrual cycle
    (2014-12) Tenan, Matthew Sheridan; Griffin, Lisa; Hackney, Anthony C; Brothers, Robert M; Marti, Carl N; Dingwell, Jonathan
    Sex hormones have in vitro effects on the nervous system. Furthermore, the effects of estradiol and progesterone metabolites have neurologic responses on the motor system, evidenced by transcranial magnetic stimulation studies. Sex hormone effects on the nervous system may underlie some of the sex discrepancies seen in athletic performance, injury and cardiovascular events. Investigating sex differences is often complicated by hormonal oscillations across the menstrual cycle; therefore, the aims of this research were to investigate sex and menstrual cycle effects on the motor and cardiovascular systems and the interaction of these two systems. In study 1, motor unit (MU) recruitment patterns of the vastus medialis (VM) and vastus medialis oblique (VMO) were examined in males and females at five menstrual cycle phases. Initial discharge rate between the VM and VMO were different only in females. This VM/VMO discharge discrepancy was only evident in females during the ovulatory and mid luteal menstrual phases. Study 2 examined the frequency domain relationship of the VM and VMO MUs between the sexes and across the menstrual cycle. Males have 256% to 741% greater odds of having coherent MU oscillations in the common drive band than females, indicating a greater common rate modulation. Further evidence indicated MU pairs from the VMO and VM/VMO have 228% and 212% greater odds of having beta band oscillations than the VM, indicating control of those muscle groups has a common cortical modulation. Study 3 looked at changes in the autonomic nervous system across the menstrual cycle via heart rate variability analysis. Heart rate variability decreases from the follicular to the luteal phases of the menstrual cycle, indicating a decrease in parasympathetic control. In study 4, the time and frequency domain relationship between electrocardiogram and MU discharge timing was examined between the sexes and across the menstrual cycle. The time domain relationship indicated that both males and females have MU time lag centered between 20-25 milliseconds, with an apparent modulation of this relationship across the menstrual cycle. The findings from this series of studies indicate that there are differences between the sexes which are often modified by the menstrual cycle in females.
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    Patterns of surface EMG following muscular endurance training
    (2011-08) Savard, Ryan Richard; Griffin, Lisa
    The delayed occurrence of fatigue while maintaining submaximal force output is a function that could be driven by the central nervous system (CNS). It has been found previously that mean EMG amplitude increases with fatigue. Endurance time has also been found to increase over repeated testing. The purpose of this study was to compare the muscle activation patterns and endurance times after training of the AdP muscle. This study analyzed surface EMG of the adductor pollicis (AdP) muscle in young, healthy adults during a sustained submaximal isometric fatiguing contraction before and after 4 weeks of muscular endurance task training. Eight participants (training group: n = 4 and control group: n = 4) carried out maximal voluntary contractions (MVCs) while sustaining isometric force of 20% MVC of thumb adduction before and after the four weeks of endurance training. EMG, recorded through surface electrodes, was measured before and after training in an effort to detect a possible CNS training effect. The endurance training group trained the AdP muscle at 20% MVC every other day for 4 weeks. Average force was calculated over 5 second time bins every 5% of endurance time (20 time bins total). A significant increase in endurance time was seen in the training group of this study. A significant effect of change for pre and post-training mean EMG amplitude across the two groups was found (p < .001). A significant interaction effect between pre and post training and control groups was also found (p = .016). There was also a significant deficit in increases of mean amplitude between the first and last time bins of the endurance task (pre and post) after training. This indicates that there is an effect of training on increasing endurance time which can be exhibited through changes in mean EMG amplitude.